
Beta 2 Microglobulin (B2M) Tumor Marker Test - MedlinePlus
What is a beta-2 microglobulin tumor marker test? A beta-2 microglobulin tumor marker test measures the amount of a protein called beta-2 microglobulin (B2M) in your body fluids. The test usually uses a sample of your blood. It may also be done using urine (pee) or in rare cases cerebrospinal fluid (CSF). B2M is a type of tumor marker.
Beta-2 microglobulin - Wikipedia
β2 microglobulin (B2M) is a component of MHC class I molecules. MHC class I molecules have α 1, α 2, and α 3 proteins which are present on all nucleated cells (excluding red blood cells). [5][6] In humans, the β 2 microglobulin protein [7] is encoded by the B2M gene. [6][8] β 2 microglobulin lies beside the α 3 chain on the cell surface.
Beta 2 Microglobulin (B2M) Test
2023年6月8日 · Beta-2 microglobulin (B2M) is a biomarker protein found on the surface of cells, including lymphocytes, and in bodily fluids. B2M is considered a tumor marker because high levels of the antigen may be indicative of certain cancers. In normal biological functioning, B2M is synthesized, excreted and reabsorbed back into the body.
Beta-2-microglobulin(β2微球蛋白)简介 - 知乎
2024年1月30日 · 本文将探讨β2微球蛋白的结构、功能以及其在疾病诊断中的应用。 β2微球蛋白是 主要组织相容性复合体 (MHC)类I分子的重要组成部分。 它与 MHC类I分子 的α链非共价结合,帮助稳定MHC类I分子的结构并促进其正确折叠。 这种结合对于将细胞内产生的肽段呈递给免疫系统的 CD8+ T细胞 至关重要,是免疫监视机制中不可或缺的一环。 β2微球蛋白使MHC类I分子能够有效地呈现肽段给CD8+ T细胞,这一过程对于识别和清除体内的病毒感染细胞和肿瘤细胞 …
β2微球蛋白_百度百科
β2-微球蛋白是由淋巴细胞、血小板、多形核白细胞产生的一种小分子球蛋白,分子质量为11800,由99个氨基酸组成的单链多肽。 它是细胞表面人白细胞抗原(HLA)的β链(轻链)部分,分子内含一对二硫键,不含糖;与免疫球蛋白稳定区的结构相似。 广泛存在于血浆、尿液、脑脊液、唾液以及初乳中。 正常人β2-微球蛋白的合成率及从细胞膜上的释放量相当恒定,β2-微球蛋白可以从肾小球自由滤过,99.9%在近端肾小管吸收,并在肾小管上皮细胞中分解破坏;故而正 …
β2-微球蛋白 - 知乎 - 知乎专栏
β2-微球蛋白 (Beta-2-microglobulin , β2-MG),是细胞表面 人类淋巴细胞抗原 (HLA)的β链(轻链)部分,分子质量为11.8kD,由99个氨基酸组成的单链多肽,主要由淋巴细胞、血小板、多形核白细胞产生。
The Implication and Significance of Beta 2 Microglobulin: A ...
β2M is critical for the immune surveillance and modulation in vertebrate animals. The dysregulation of β2M is associated with multiple diseases, including endogenous and infectious diseases. β2M could directly participate in the development of cancer cells, and the level of β2M is deemed as a prognostic marker for several malignancies.
Beta 2 Microglobulin (B2M) Blood Test: Low, High, Normal Levels
2024年4月25日 · The Beta-2 Microglobulin (B2M) blood test is an important diagnostic tool used to measure the level of beta-2 microglobulin in the blood. This protein, part of the major histocompatibility complex (MHC) class I molecules, plays a role in the immune system and can be elevated in certain diseases.
Beta 2 microglobulin, test, normal range & causes of high beta 2 ...
Beta-2 microglobulin is a low-molecular-weight protein that forms the heavy chains component of class I histocompatibility (HLA: human leukocyte antigen) antigens. Beta-2 microglobulin is a protein that is found on the surface of almost all cells (nucleated cells) in your body and functions as part of the human immune system.
人β2-微球蛋白——科研专用 - 每日生物评论
2021年6月1日 · β2-微球蛋白(B2M)是细胞膜上组织相容性复合体(MHC,一组编码人类白细胞表面抗原HLA基因群的通称)轻链结构的组成部分,在正常细胞新陈代谢过程中与MHC分离后释放入血。 β2-微球蛋白(B2M)分布于几乎所有有核细胞(尤其在淋巴细胞和单核细胞存在丰富)和生物体液,包括血清、尿液和(关节)滑液。 正常人β2-微球蛋白具有以下特点:(1)浓度相对恒定;(2)重吸收后被降解。 血清β2-微球蛋白极易通过肾小球滤过膜,滤过的β2-微球蛋 …