β-Melanocyte-stimulating hormone (β-MSH) is an endogenous peptide hormone and neuropeptide. [1] It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC). [1] It is an agonist of the MC 1, MC 3, MC 4, and MC 5 receptors. [1] It contains 23 amino acid ...

2024年3月6日 · In vitro, we show that β-MSH signals comparably to α-MSH at melanocortin receptors. These data implicate β-MSH and β-endorphin as important in determining hunger and moderating energy expenditure and suggest that this role …

Beta-MSH (beta-melanocyte stimulating hormone), a peptide hormone found primarily in the intermediate lobe of the pituitary gland, is a melanocortin receptor agonist. As the human pituitary lacks a distinct intermediate lobe, the source and function of beta-MSH in humans is unknown.

The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides consisting of α-melanocyte-stimulating hormone (α-MSH), β-melanocyte-stimulating hormone (β-MSH), and γ-melanocyte-stimulating hormone (γ-MSH) that are produced by cells in the pars ...

黑素细胞刺激素（melanocyte-stimulating hormone，MSH）， 两栖类 垂体中间叶产生的一种激素。 人类垂体中间叶退化只留痕迹。 产生MSH的细胞分散在垂体前叶。 有α与β两种MSH。 α为13肽，β为18肽，人垂体中黑素细胞刺激素的绝大部分为β，αMSH不到3%。 正常人垂体中MSH为300～400微克/克湿重，血浆中β-MSH含量约20～110微微克/毫克/毫升ml。 半衰期 为30分钟。 MSH主要作用于 黑色素细胞。 体内 黑色素细胞 分布于皮肤及毛发、眼球 虹膜 色素层及视网 …

alpha-Melanocyte stimulating hormone (MSH) has generally been assumed to be the endogenous ligand acting at the melanocortin-4 receptor (MC4-R), activation of which in the hypothalamus leads to reduced feeding. However, beta-MSH is also capable of activating MC4-R and inhibiting feeding. Here, we in …

Most research effort has focused on alpha-melanocyte-stimulating hormone (alpha-MSH) as the predominant POMC-derived neuropeptide in the central regulation of human energy balance and body weight. Here we report a missense mutation within the coding region of the POMC-derived peptide beta-MSH (Y5C-beta-MSH) and its association with early-onset ...

An 18-amino acid peptide that is the C-terminal fragment of gamma-lipotropin which is the N-terminal fragment of BETA-LIPOTROPIN. Beta-MSH is shown to regulate skin pigmentation, steroid production, and feeding.

It is generally accepted that human beta-melanocyte-stimulating hormone (h beta MSH) does not normally exist in humans but was merely an artifactually generated 22-amino acid peptide corresponding to a lipotropin (LPH) fragment (residues 35-56).

人类β-黑素细胞刺激激素 (MSH) 是一种 22 肽，是内源性黑皮质素 4 受体（melanocortin-4 受体；MC4-R）激动剂。 转染到 CHO 细胞中的 MC4-R (Ki = 11.4±0.4 nM) 和大鼠下丘脑匀浆中的 MC4-R (Ki = 5.0±0.4) 均受到人 β-黑素细胞刺激激素 (MSH) (β-MSH) 的影响，具有高亲和力纳米） [1]。 [1]. beta-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides. 2003 Mar;24 (3):397-405.