Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins.

2024年12月24日 · ACTB (Actin Beta) is a Protein Coding gene. Diseases associated with ACTB include Thrombocytopenia 8, With Dysmorphic Features And Developmental Delay and Baraitser-Winter Syndrome 1 . Among its related pathways are Signaling downstream of RAS mutants and Regulation of actin dynamics for phagocytic cup formation .

The ACTB gene provides instructions for making a protein called beta (β)-actin, which is part of the actin protein family. Proteins in this family are organized into a network of fibers called the actin cytoskeleton, which makes up the structural framework inside cells.

In vertebrates, three main groups of actin isoforms, alpha, beta, and gamma have been identified. The alpha actins, found in muscle tissues, are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility.

β-Actin Antibody detects endogenous levels of β-actin. Due to the high sequence identity between the actin isoforms, β-Actin Antibody may cross-react with other actin isoforms.

The ACTB gene encodes beta-actin, which is essential for a number of cytoplasmic functions, such as regulation of cell shape and migration, as well as nuclear functions, such as regulation of gene expression, cell division, and proliferation (summary by Cuvertino et al., 2017).

2015年11月27日 · Beta-actin control provides assurance that effect you see in protein expression is not due to overall protein synthesis change. For example, if you study some illness, it might cause change in metabolism, weight loss, loss of ability to synthesize different proteins or absorb amino acids from diet.

2019年1月14日 · Beta-actin is commonly used as a western blot loading control as is expressed within all eukaryotic cell types and is not affected by cellular treatments. Beta-actin is approximately 42 kDa and...

2016年11月16日 · Actin is one of the most abundant proteins in any eukaryotic cell and an indispensable component of the cytoskeleton. In mammalian organisms, six highly conserved actin isoforms can be distinguished, which differ by only a few amino acids.

2023年12月20日 · The actin beta (ACTB) gene plays a vital role in genetic engineering. This gene encodes for the production of beta-actin, a key component of the cytoskeleton in cells. Beta-actin is involved in various cellular processes, including …