Emerging evidence suggests that not only beta-amyloid but also other amyloid precursor protein (APP) fragments, such as the beta-C-terminal fragment (betaCTF), might be involved in …

2009年10月14日 · Amyloid beta protein (Abeta), a pathogenic molecule associated with Alzheimer's disease, is produced by gamma-secretase, which cleaves the beta-carboxyl …

To explore the impact of APP lowering on endolysosomal dysfunction, we evaluated the effect of an siRNA targeting APP mRNA on downstream APP cleavage products, including beta …

2010年1月26日 · By contrast, endosomal pathology can be induced in normal disomic (2N) fibroblasts by overexpressing APP or the C-terminal APP fragment generated by BACE-1 …

2010年7月1日 · We established a methodology to generate recombinant gamma-secretase substrates with bona fide N-terminal sequence. gamma-Secretase substrates, such as …

By combined biochemical, immunohistochemical and ultrastructural approaches, we demonstrate a link between EAL pathology and the intraneuronal accumulation of the β-secretase-derived …

Neuronal expression of β-CTF in mouse brains resulted in defective synaptic transmission and cognitive impairments, even in the absence of amyloid plaques. These findings unveil a β-CTF …

2022年1月10日 · We demonstrated the effects of APP-CTFs-related pathology using induced neural stem cells (iNSCs) from AD patient-derived fibroblasts. APP-CTFs accumulation was …

2014年7月1日 · Abeta is generated by the gamma-secretase-catalyzed proteolysis of amyloid precursor protein (APP) C-terminal fragment (APP-betaCTF) that is released by the beta …

2024年7月16日 · These findings unveil a beta-CTF-initiated mechanism driving synaptic toxicity irrespective of amyloid plaque formation and suggest a potential intervention by inhibiting the …