2006年5月1日 · In this study, we demonstrate that administration of TAT-Bcl-x L and TAT-BH4 provided highly significant protection both in vitro and in vivo against bacterial-induced lymphocyte apoptosis. We conclude that TAT-conjugated BH4 may offer a novel means to prevent the profound immune cell depletion that is central to the pathophysiology of sepsis.

2003年11月20日 · We have previously reported that BH4 peptide fused to the protein transduction domain of HIV-1 TAT protein (TAT-BH4) significantly inhibits etoposide-induced apoptosis in a cell line. This...

2006年5月1日 · TAT-Bcl-x(L) and TAT-BH4 prevented Escherichia coli-induced human lymphocyte apoptosis ex vivo and markedly decreased lymphocyte apoptosis in an in vivo mouse model of sepsis. In conclusion, TAT-conjugated antiapoptotic Bcl-2-like peptides may offer a novel therapy to prevent apoptosis in sepsis and improve survival.

2009年4月15日 · Here, we demonstrate that the BH4 domain of the anti-apoptotic protein, Bcl-x (L), attached to the membrane transport peptide, TAT, reduces stroke injury after intracerebroventricular infusion into immature rats subjected to carotid artery ligation and additional exposure to hypoxia.

2007年2月20日 · In this paper we demonstrate that BH4 domain of Bcl-xl administrated to endothelial cells as the conjugated form with TAT peptide, reverts Aβ-induced apoptotic cell death by activating a survival programme which is Akt/endothelial nitric oxide synthase dependent.

Recently, we showed that BH4 domain of Bcl-xL is essential for the prevention of apoptosis, and that BH4 fused to HIV TAT protein (TAT-BH4) prevented apoptotic cell death. Then, we hypothesized TAT-BH4 may attenuate ischemia/reperfusion injury in rat hearts.

2018年5月10日 · Anti-apoptotic B-cell lymphoma (Bcl)-2-family members, such as Bcl-2 and Bcl-X L, have emerged as important modulators of IP 3 Rs and RyRs. These proteins contain four Bcl-2 homology (BH) domains...

TAT-BH4 is a fusion peptide that combines the N-terminal cysteine conjugated protein transduction domain of HIV TAT protein (amino acids 49 to 57) with the Bcl-xL BH4 peptide. TAT-BH4 can be used for research of diseases caused by accelerated apoptosis [1] .

In the present study, we investigated the effects of sepsis-induced apoptosis in Bcl-x L transgenic mice and in wild-type mice treated with an antiapoptotic TAT-Bcl-x L fusion protein and TAT-BH4 peptide.

2006年6月1日 · TAT-Bcl-x (L) and TAT-BH4 prevented Escherichia coli-induced human lymphocyte apoptosis ex vivo and markedly decreased lymphocyte apoptosis in an in vivo mouse model of sepsis. In conclusion,...