One of the main anti-inflammatory response mediators is bikunin (Bik) that is responsible for inhibiting the activity of many serine proteases such as trypsin, thrombin, chymotrypsin, kallikrein, plasmin, elastase, cathepsin, Factors IXa, Xa, XIa, and XlIa.

2000年2月1日 · It was recently discovered, however, that bikunin effectively inhibits a proteinase that seems to be involved in the metastasis of tumour cells — cell surface plasmin — and that a fragment of bikunin inhibits two proteinases of the coagulation pathway …

2011年10月9日 · Bikunin, the simplest proteoglycan, with a single glycosaminoglycan chain, is a serine protease inhibitor used to treat acute pancreatitis. Unlike nucleic acids and proteins, whose synthesis is...

2007年1月1日 · Bikunin (Bik), a peptide excreted in the urine, is one of the primary inhibitors of the trypsin family of serine proteases. This peptide plays a key role in inflammation and innate immunity because of its two Kunitz‐type binding domains [[1], [2]].

双库尼茨抑制剂是一种化学分子式，属于生物化学与分子生物学。 分子中含有两个库尼茨 (Kunitz)型的 胰蛋白酶抑制剂 结构域，即一个抑制剂分子可以结合二分子的胰蛋白酶，是一种含有 硫酸软骨素 糖链的蛋白聚糖。 分子中含有两个库尼茨 (Kunitz)型的胰蛋白酶抑制剂结构域，即一个抑制剂分子可以结合二分子的胰蛋白酶，是一种含有硫酸软骨素糖链的蛋白聚糖。 双库尼茨抑制剂是一种化学分子式，属于生物化学与分子生物学。 分子中含有两个库尼茨 (Kunitz)型的胰蛋白 …

2022年11月21日 · Bikunin is a small chondroitin sulfate proteoglycan (PG) with Ser-protease inhibitory activity that plays pleiotropic roles in health and disease. It is involved in several physiological processes including stabilization of the extracellular matrix (ECM) of connective tissues and key reproductive events.

The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type Protease Inhibitors ...

Inter-α-trypsin inhibitor (IαI) family members are ancient and unique molecules that have evolved over several hundred million years of vertebrate evolution. IαI is a complex containing the proteoglycan bikunin to which heavy chain proteins are covalently attached to …

Bikunin可以通过抑制尿激酶型纤溶酶原激活剂 (uPA)、调节有关信号传导途径等机制抑制卵巢癌的浸润和转移.裸鼠体内实验已证实Bikunin的治疗作用.临床观察表明Bikunin水平与卵巢癌患者预后有关.现将Bikunin的结构和来源、抑制卵巢癌浸润及转移的机制、临床应用等 ...

2020年6月24日 · Bikunin, a chondroitin sulfate (CS) proteoglycan clinically used to treat acute inflammation and sepsis, contains a CS chain with more than 20 monosaccharide units. To understand the function of the CS chain of bikunin, synthesis of long CS chains is needed.