Doramapimod (BIRB 796) is an orally active, highly potent p38 MAPK inhibitor, which has an IC 50 for p38α=38 nM, for p38β=65 nM, for p38γ=200 nM, and for p38δ=520 nM. Doramapimod …

BIRB 796 is a high affinity and selective p38 kinase inhibitor (K d = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNF α production in …

BIRB-796 (also known as doramapimod) is one of the most potent compounds that targets a diaryl urea class allosteric binding site, indirectly competes with the binding of adenosine 5′ …

2005年5月20日 · The compound BIRB796 inhibits the stress-activated protein kinases p38alpha and p38beta and is undergoing clinical trials for the treatment of inflammatory diseases. Here …

BIRB 796，又称为BIRB-796、Doramapimod，是一种高效的p38 MAPK抑制剂 (Kd=0.1 nM) ，在LPS刺激的THP-1细胞中BIRB 796可以抑制TNF α释放 (IC 50 =18 nM) 。另外，BIRB 796抑 …

BIRB-796 is a highly potent inhibitor of p38 MAPK (Kd = 0.1 nM) that blocks TNFα release in LPS-stimulated THP-1 cells (IC₅₀ = 18 nM) (Pargellis et al.). At 10 μM, BIRB-796 can also inhibit …

Doramapimod GMP (BIRB 796 GMP) is an orally active inhibitor for p38 MAPK, with IC 50 s of 38, 65, 200 and 520 nM, for p38α, p38β, p38γ, p38δ. Doramapimod exhibits cytotoxicity and …

birb 796是作用于人类p38 mapk的最有效和分离最慢的抑制剂之一。 BIRB 796 有效抑制c-Raf-1和Jnk2α2，IC50分别为1.4和0.1nM。 高浓度BIRB796也抑制SAPK3/p38γ的活性和激活。

BIRB-796 inhibits the stress-activated p38 mitogen-activated protein kinase (MAPK), which plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis …

2019年12月26日 · BIRB 796 (p38 MAPK抑制剂)是一种高效的p38α抑制剂，IC50为4 nM，也抑制B-Raf和Abl，IC50分别为83 nM和14.6μM。 由于其在T细胞增殖和细胞因子产生中的作用，通 …