Bisphosphonates are a class of medications that help treat osteoporosis. Healthcare providers also prescribe them for other conditions that affect the density and strength of your bones and for some conditions that cause very high blood calcium (hypercalcemia). Cleveland Clinic is a non-profit academic medical center.

Bisphosphonates are a group of medicines that slow down or prevent bone loss, strengthening bones. Bisphosphonates inhibit osteoclasts which are responsible for breaking down and reabsorbing minerals such as calcium from bone (the process is known as bone resorption).

Bisphosphonates are a class of drugs that prevent the loss of bone density, used to treat osteoporosis and similar diseases. They are the most commonly prescribed drugs used to treat osteoporosis. [1] . They are called bisphosphonates because …

2023年7月3日 · Bisphosphonates define a class of drugs widely indicated since the 1990s to treat osteoporosis both in men and women. Their effectiveness in treating osteoporosis and other conditions is related to their ability to inhibit bone resorption.

2021年4月21日 · Bisphosphonates, also known as diphosphonates, are a class of drugs that have been used commonly for more than two decades for the treatment and prevention of osteoporosis. Bisphosphonates slow bone resorption by reducing osteoclast function.

Bisphosphonates are primary agents in the current pharmacological arsenal against osteoclast-mediated bone loss due to osteoporosis, Paget disease of bone, malignancies metastatic to bone, multiple myeloma, and hypercalcemia of malignancy.

2024年10月18日 · Bisphosphonates are prescription drugs that improve bone density. They’re used to treat several conditions associated with bone loss, including osteoporosis, and to...

2022年3月15日 · Bisphosphonates are a class of medications that slow down and prevent bone loss. Used to increase bone strength and reduce the risk of bone fractures, bisphosphonate medications help treat osteoporosis, Paget’s disease, and other conditions that may lead to a loss of bone mineral density.

steoblast cells replace it with new bone. Bisphosphonates work by stopping th. removal of old bone osteoclast activity. As we age and in certain diseases, the bone is actually being removed or damaged fa. ter than your body is able to replace it. This …

2016年11月2日 · Bisfosfonater, som är den helt dominerande läkemedelsgruppen för behandling av osteoporos, binder till hydroxiapatit i skelettet, vilket leder till hämning av osteoklaster. De beredningsformer som rekommenderas är intravenös infusion som ges årligen (zoledronsyra) eller veckotablett.

Bisphosphonates are widely prescribed and highly effective at limiting the bone loss that occurs in many disorders characterized by increased osteoclast-mediated bone resorption, including senile osteoporosis in both men and women, glucocorticoid-associated osteoporosis, and malignancies metastatic to bone.

Bisphosphonates can be administered orally or intravenously with a wide range of doses and dosing intervals. Randomized placebo-controlled clinical trials have shown that bisphosphonates reduce fracture risk in postmenopausal women with osteoporosis and have a …

2017年9月1日 · Osteoporosis in postmenopausal females: Oral: Prophylaxis: 5 mg once daily or 35 mg once weekly. Treatment: 10 mg once daily or 70 mg once weekly. Osteoporosis in males: Oral: 10 mg once daily or 70 mg once weekly.

2011年11月17日 · Bisphosphonates work by slowing down the cells which break down bone (osteoclasts). Therefore they slow down bone loss, allowing the bone cells (osteoblasts) that help to build the bone to work more effectively. They can help to strengthen bone and help to prevent it getting any weaker.

2010年11月18日 · Bisphosphonates reduce fractures by suppressing bone resorption. 12,13 The molecular structure of the bisphosphonates (P-C-P) is analogous to that of the naturally occurring pyrophosphates...

Bisphosphonates (BP) are a class of calcium-binding drug used to prevent bone resorption in skeletal disorders such as osteoporosis and metastatic bone disease. They act by selectively targeting bone-resorbing osteoclasts and can be grouped into two classes depending on their intracellular mechanisms of action.

Bisphosphonates are medicines used to treat bone diseases such as osteoporosis and Paget’s disease. Alendronate and risedronate are the most commonly prescribed bisphosphonate tablets in Australia.

Because bisphosphonates inhibit bone resorption, they are used in the treatment of hypercalcemia, osteoporosis, metastatic bone disease, and Paget disease. These uses are discussed separately. Bisphosphonates all have in common the P-C-P structure, which is similar to the P-O-P structure of native pyrophosphate (figure 1) [1].

Bisphosphonates are inhibitors of bone resorption. They increase bone mineral density by altering osteoclast activation and function. Alendronate and risedronate are generally the first-line treatments for osteoporosis in primary care. What are the contraindications and cautions for bisphosphonates?

Bisphosphonates are a group of drugs that work by slowing bone loss. They reduce the risk of hip and spine fractures. Bone renewal is a slow process, but in many people an increase in bone density can be measured over five years of treatment. Bisphosphonates can be used to reduce the risk of hip and spine fractures in osteoporosis.