PRDM1/BLIMP-1 is a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid lineage cell differentiations.

BLIMP1 regulates ASC differentiation. The finding that enforced expression of BLIMP1 in B-cell lines or in primary splenocytes drives the differentiation of mature B cells to the plasma-cell...

B淋巴细胞诱导成熟蛋白1 (B lymphocyte-induced maturation protein 1，Blimp-1)是一种调节B淋巴细胞和T淋巴细胞功能的重要转录分子。 在抗原刺激B淋巴细胞分化为浆细胞分泌抗体的过程 …

该研究揭示了 B 淋巴细胞诱导成熟蛋白 -1（Blimp-1）在脓毒症中调控巨噬细胞极化和代谢稳态的新机制，为脓毒症的治疗提供了潜在的新靶点，对深入理解脓毒症的病理生理过程和开发新的 …

2022年1月26日 · In B cells, Blimp1 drives plasmablast formation and antibody secretion, whereas in T cells, Blimp1 regulates functional differentiation, including cytokine gene expression. …

2016年1月18日 · Blimp-1 promoted the migration and adhesion of plasmablasts. It directly repressed genes encoding several transcription factors and Aicda (which encodes the cytidine …

B lymphocyte-induced maturation protein-1 (Blimp-1) serves as a master regulator of the development and function of antibody-producing B cells. Given that its function in T …

1 天前 · Blimp-1 is a master regulator of plasma cell differentiation, guiding the transition from antibody-producing B cells to fully matured plasma cells. This process begins when activated …

In addition, IL-10 is found to upregulate AIM2 expression via DNA demethylation. Together, our findings reveal that AIM2 is highly expressed in the B cells of lupus patients and promotes B …

2013年5月1日 · Blimp-1 orchestrates plasma cell differentiation by silencing the gene expression program of mature B cells. We showed that long-lived plasma cells in the bone marrow require …