2017年4月15日 · Protein target information for Neurotoxin BmK-M10 (Chinese scorpion). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2023年11月1日 · The primary sequences and 3D structures of representative scorpion venom peptides with disulfide bridges. (A) Sequences and properties of five representative peptides in different groups. (B) The structure of BmK-M10 classified into the NaTx group. (C) The structure of BmKTX classified into the KTx group.

Binds to voltage-dependent sodium channels (Nav) and voltage-dependent delayed rectifier potassium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Administration to mice at a dosage of 0.8 mg/kg produces an analgesic effect. Showing features for signal, chain, disulfide bond, propeptide.

2020年1月16日 · Neurotoxins purified from Chinese scorpion Buthus Martensii Karsch (BmK) are considered as the main active ingredients, which act on membrane ion channels. Long-chain toxins of BmK, composed of 58–76 amino acids, could specifically recognize voltage-gated sodium channels (VGSCs).

本研究确定了大肠杆菌系统可以作为bmk-m10的获取途径，为核磁共振波谱法研究bmk-m10结构提供了条件。 3、通过M9培养基获得进行 15 N标记的重组蛋白，采用核磁共振方法解析多肽的空间结构，为证明BMK-M10蛋白的结构与活性机制关系提供了科学依据。

Knottins are small proteins characterised by a cystine-knot [ (PUBMED:18025039) ]. They constitute a large family of structurally related peptides with diverse biological functions, including inhibitors, anti-microbial peptides and toxins [ (PUBMED:15551519) ].

2024年5月1日 · Buthus martensii Karsch (BmK) Scorpion is listed as medicinal and functional food material for centuries to relieve neurological diseases including glioma in traditional Chinese medicine. In this study, network pharmacology firstly revealed that BmK Scorpion may exert anti-tumor effect via regulating oncogenic signals like EGFR and SRC.

Binds to voltage-dependent sodium channels (Nav) and voltage-dependent delayed rectifier potassium channels and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Administration to mice at a dosage of 0.8 mg/kg produces an analgesic effect. Secreted. Expressed by the venom gland.

对BmK-M10和BmKITc进行抗血栓活性筛选,小鼠黑尾试验与大鼠体内血栓形成试验表明,两者均有抗血栓活性,以BmKITc效果最佳。 斑马鱼抗血栓活性筛选试验表明,BmK-M10和BmKITc均有抗血栓活性,其中BmK-M10随着浓度增高,尾部血管红细胞染色强度值增大,呈现反向结果;BmKITc随着浓度增高,尾部血管红细胞染色强度值减小,呈浓度依赖性结果。...

Solution Structure of BmK-M10 . PDB DOI: https://doi.org/10.2210/pdb2KBK/pdb; Classification: TOXIN; Organism(s): Olivierus martensii; Mutation(s): No ; Membrane Protein: Yes OPM; Deposited: 2008-11-28 Released: 2009-12-22 ; Deposition Author(s): Zhu, J., Wu, H.