Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene. [5][6] BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins. [6] It is a novel protein that, unlike most other BMP's, is likely to …

2024年12月24日 · BMP10 (Bone Morphogenetic Protein 10) is a Protein Coding gene. Diseases associated with BMP10 include Myostatin-Related Muscle Hypertrophy and Pulmonary Hemosiderosis. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

编码的前原蛋白经过蛋白水解处理生成成熟蛋白，该蛋白与激活素受体样激酶 1 (ALK1) 结合并在心血管发育中发挥重要作用，包括心肌细胞增殖和心脏大小的调节、动脉导管的闭合、血管生成和心室小梁。 [RefSeq 提供，2016 年 8 月] This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins.

2025年1月4日 · Low expression of bone morphogenetic protein-10 is associated with urothelial cancer of the bladder. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.

2023年3月19日 · 近日，心血管疾病领域权威杂志JAHA上发表了一篇研究文章，研究人员的目的是评估新型心房特异性生物标志物骨形态发生蛋白10（BMP10）对房颤患者死亡和MACE的预测价值，并与NT-proBNP进行比较。

2023年1月14日 · Bone morphogenetic protein 10 (BMP10) is a protein expressed in the atrial myocardium. We evaluated the association between BMP10 and the risk of ischaemic stroke and other cardiovascular events in large cohorts of patients with AF, treated with and without oral anticoagulation (OAC).

Title: Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation. Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10.

Unlike other ligands of the TGF-β family, BMP-9 and -10 are secreted as a mixture of disulfide-linked dimers and monomers in which the interchain cysteine (Cys-392) remains either unpaired or paired. Here, we show that the monomers are secreted in a cysteinylated form that crystallizes as a non-covalent dimer.

BMP10 is a newly identified cardiac‐specific protein. In recent years, reports have emphasized the effects of BMP10 on myocardial apoptosis, fibrosis and immune response, as well as its synergistic effects with BMP9 in vascular endothelium and role in endothelial dysfunction.

BMP-10 对于胚胎心肌细胞增殖至关重要，可防止 CDKN1C/p57KIP 过早激活并确保 MEF2C 和 NKX2-5 的最佳表达。 作为 AVRL1/ALK1、BMPR1A/ALK3 和 BMPR1B/ALK6 的配体，它激活 SMAD1、SMAD5 和 SMAD8，调节关键信号通路。