Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in humans is encoded by the growth differentiation factor 11 gene. [5] . GDF11 is a member of the Transforming growth factor beta family. [6]

bmp11可能是结直肠癌患者的诊断和预后标志物。 BMP3失活似乎在早期息肉形成和结直肠癌发展中非常重要。 BMPR-1A、BMPR-1B、BMPR-2、BMP2，BMP4都与结肠癌的发病风险有关，最高危的表型会增加20-30%的风险。

骨形态发生蛋白 11 (BMP-11; GDF11)，又称生长/分化因子 11，是一种多效配体蛋白，属于 TGFβ 家族。 骨形态发生蛋白 11 信号通过激活素受体 II 型、ACVR2A 和 ACVR2B，以及激活素受体 I 型、ACVR1B、ACVR1C 和 TGFBR1，导致 SMAD2 和 SMAD3 磷酸化 [1]。 骨形态发生蛋白 11 与生长/分化因子 8 (GDF8) 高度相似，与 GDF8 相比，骨形态发生蛋白 11 表现出更强的 SMAD2/3 激活作用，并通过 I 型激活素样受体激酶受体 ALK4/5/7 发出更有效的信号。 此外，骨形态发 …

Bone morphogenetic protein 11 (BMP11) is a key regulatory protein in skeletal development. BMP11 propeptide has been shown to antagonize GDF11 activity in vitro. To explore the role of BMP11 propeptide in skeletal formation in vivo, we generated transgenic mice with skeleton-specific overexpression of BMP11 propeptide cDNA.

Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11, a member of the transforming growth factor-β superfamily, has been reported to be involved in colorectal cancer. However, the roles of GDF11 in Chinese patients with liver cancer and the underlying mechanisms have remained elusive.

Growth differentiation factor (GDF11), also called as bone morphogenetic protein 11 (BMP11) belongs to the transforming growth factor-β (TGF-β) superfamily. GDF11 was first reported in 1999 as a novel differentiation factor for odontoblasts [1]. Since then, many studies have investigated its distribution, structure and signaling mechanisms.

The present study investigates crucial roles of BMP11 in cultured 3T3-L1 white and HIB1B brown adipocytes, using Bmp11 gene depletion and pharmacological inhibition of BMP11. The silencing of Bmp11 markedly decreases the expression levels of brown-fat signature proteins and beige-specific genes in white adipocytes and significantly down ...

2024年12月25日 · GDF11 (Growth Differentiation Factor 11) is a Protein Coding gene. Diseases associated with GDF11 include Vertebral Hypersegmentation And Orofacial Anomalies and Orofacial Clefting Syndrome. Among its related pathways is …

BACKGROUND Growth differentiation factor 11 (GDF-11), also known as bone morphogenic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling.

2014年9月1日 · BMP12 signaling in the spinal cord leads to differentiation of specific neuron classes, suggesting a role for BMPs in determining neuron identity in the CNS. 81 BMP11 is also involved in spinal cord neurogenesis through its ability to induce cell cycle exit and instead promote differentiation of progenitors. 74 On the other hand BMP11, secreted ...