2024年12月24日 · BMPR1A (Bone Morphogenetic Protein Receptor Type 1A) is a Protein Coding gene. Diseases associated with BMPR1A include Polyposis Syndrome, Hereditary Mixed, 2 and Juvenile Polyposis Syndrome. Among its related pathways are …

The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292). [5]

2023年6月21日 · 骨形态发生蛋白受体 (BMPR) 家族属于跨膜蛋白，可识别并与骨形态发生蛋白 (BMP) 结合。 BMP是转化生长因子β (TGF-β) 超家族的一类重要成员，在生物体中具有多种功能，包括细胞生长、分化、凋亡以及骨、软骨和其他组织的形成和修复。 BMPR家族成员共有11个，分为 I 型和 II 型受体两类。 I 型受体包括 ALK1 、ALK2、ALK3 (BMPR1A) 和 ALK6 (BMPR1B)，能够与BMP家族成员结合并启动下游信号通路。 II 型受体包括BMPR2、ActRII …

The BMPR1A gene provides instructions for making a protein called bone morphogenetic protein receptor 1A. This receptor protein has a specific site into which certain other proteins, called ligands, fit like keys into locks. Specifically, the BMPR1A protein attaches (binds) to ligands in the transforming growth factor beta (TGF-β) pathway.

2024年12月24日 · BMPR1B (Bone Morphogenetic Protein Receptor Type 1B) is a Protein Coding gene. Diseases associated with BMPR1B include Acromesomelic Dysplasia 3 and Brachydactyly, Type A1, D. Among its related pathways are Akt Signaling and NF-kappaB Pathway.

该基因的人类直系同源基因与遗传性混合性息肉病综合征 2 相关；肠道疾病；和幼年息肉病综合征。 与人类 BMPR1A（1A 型骨形态发生蛋白受体）同源。 [由基因组资源联盟提供，2022 年 4 月] Enables BMP binding activity; BMP Receptor activity; and Enzyme activator activity.

骨形态发生蛋白受体（BMPR）家族由跨膜受体组成，在细胞信号转导和组织发育中发挥着重要作用。 BMPR 家族包括 I 型和 II 型受体 1。 I 型受体包括 BMPR1A （也称为 ALK3）和 BMPR1B (ALK6)，而 II 型受体包括 BMPR2 和 ActRII （激活素 II 型受体）亚型。 这些受体具有独特的配体结合特异性并介导不同的信号级联反应，但也可以与其他 TGF-β 家族配体发生交叉相互作用 2。 BMPR1A 和 BMPR1B 对于影响骨重建的成骨细胞分化和软骨形成至关重要 2。 此外，BMPR …

2020年9月1日 · Bone morphogenetic proteins (BMPs) are secreted cytokines that control the fate and function of many different cell types. They exert their cellular responses via heteromeric complexes of specific BMP type I and type II serine/threonine kinase receptors, e.g. …

2018年9月27日 · Downstream analysis demonstrated that BMP4 controls the expression of the survival factor ΔNp73 through its binding to BMPR1A. At the functional level, this results in the direct induction of NANOG...

We previously demonstrated that augmentation of BMP signaling mediated by a constitutively active BMP type IA receptor (ca-BmpR1A) in neural crest cells (ca1A hereafter) causes craniosynostosis and superimposition of heterozygous null mutation of Bmpr1a rescues premature suture fusion (ca1A;1aH hereafter).