2025年1月28日 · BM mesenchymal stromal cells (BMSCs) supply cap-dependent translation machinery to AML cells via extracellular vesicles. Targeting this mechanism with specific inhibitors reveals BMSC-AML translational crosstalk as a potential driver of AML recurrence.

We have studied the contribution of nestin + BM mesenchymal stem cells (BMSCs) to MLL-AF9-driven acute myeloid leukemia (AML) development and chemoresistance in vivo. Unlike bulk stroma, nestin + BMSC numbers are not reduced in AML, but their function changes to support AML cells, at the expense of non-mutated hematopoietic stem cells (HSCs).

2024年11月21日 · We explored the effects and mechanism of BMSC-exos on AML cell proliferation and apoptosis. Methods: Human AML cells (MOLM-16, MV-4-11) and normal human hematopoietic cells (GM12878) cultured in vitro were treated with exos extracted from BMSCs that transfected with microRNA (miR)-139-5p-mimics, ovβ-catenin, or miR-139-5p-inhibitor.

2021年3月15日 · We established a stringent flow cytometric protocol for the prospective isolation of a CD73 + CD105 + CD271 + BMSC subpopulation from uncultivated cryopreserved BM of MDS and AML patients as...

2016年11月11日 · Thus we assessed genome-wide genetic, transcriptional and epigenetic alterations in BM-MSC derived from AML patients (AML BM-MSC). Whole-exome sequencing (WES) of AML BM-MSC samples from 21...

Bone marrow stromal cells (BMSC) in acute myeloid leukaemia (AML) contribute to extrinsic drug resistance, generally attributed to cell–cell contact or secreted cytokines (Jacamo et al, 2014). However, a recent report indicates that stromal protection may also occur via other soluble factors (Yang et al, 2014).

2020年11月3日 · Nestin + BMSCs support survival and chemotherapy relapse of AML through increased oxidative phosphorylation, tricarboxylic acid (TCA) cycle activity, and glutathione (GSH)-mediated antioxidant defense. Therefore, AML cells co-opt energy sources and antioxidant defense mechanisms from BMSCs to survive chemotherapy.

6 天之前 · Growing evidence underscores the pivotal impact of crosstalk between leukemic stem cells (LSCs) and mesenchymal stromal cells (MSCs) within their niche on leukemia initiation, progression, and therapy response. Although MMP14 plays an important role in inflammation and cancer, the regulation and role of MSC-derived MMP14 in acute myeloid leukemia (AML) are largely unknown. Here, we found that ...

Bone marrow mesenchymal stem cells (BMSCs) in acute myeloid leukemia (AML) microenvironment undergo modification that includes expression of contents in the small-sized extracellular vesicles (EVs) they secrete. This study aims to investigate whether small-sized EVs from BMSCs of AML patients regula …

MLL-AF9-driven AML development and resistance to conven-tional chemotherapy in vivo. The results demonstrate that nestin+ cells contribute to AML progression by increasing the bioenergetic capacity of AML cells and facilitating their chemo-resistance. BMSC-dependent increased OXPHOS, tricarbox-