2017年4月1日 · Our study showed that BMSCs seeded on MNT substrates exhibited higher YAP level and promoted YAP nuclear translocation and YAP transcriptional activity, which resulted in enhanced osteogenic and depressed adipogenic performance on hierarchical structure.

2023年4月6日 · Here, we show that matrix stiffness fine-tunes HSC niche factor expression by bone marrow stromal cells (BMSCs). Increased stiffness activates Yap/Taz signaling to promote BMSC expansion upon 2D culture, which is largely reversed by 3D culture in soft gelatin methacrylate hydrogels.

2024年5月17日 · The mechanisms by which bone marrow stromal cells (BMSCs) maintain multilineage potency in vitro remain elusive. To identify the transcriptional regulatory circuits that contribute to BMSC multipotency, we performed paired single-nucleus multiomics of the expansion of freshly isolated BMSCs and of B …

2018年6月1日 · Expression of β-catenin in YAP-deficient BMSCs (bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for...

Bone marrow mesenchymal stem cell (BMSC)-derived small extracellular vesicles (BMSC-sEVs) may represent a safer and more effective treatment, but their role in TMJOA has not been elucidated. This study attempted to analyze the cartilage reconstruction effect of BMSC-sEVs on TMJOA and the mechanism underlying this effect.

进一步消除细胞骨架张力可抑制YAP功能，这证实了YAP介导的机械转导在BMSC分化中的关键作用。 这些结果共同提供了有关干细胞命运在分层结构上的承诺的信息，以及通过关注特定的机械转导过程来设计先进生物材料的有前途的方法。 YAP活性增加和核易位的证据显示在层次结构上，YAP敲低抑制了由层次结构诱导的成骨分化并促进了成脂分化。 进一步消除细胞骨架张力可抑制YAP功能，这证实了YAP介导的机械转导在BMSC分化中的关键作用。 这些结果共同提供了有 …

2019年10月1日 · To test this, we analyzed cell functions, AMOT130 expression, and YAP intracellular distribution of rat bone marrow mesenchymal stem cells (BMSCs) cultured on Ti surfaces with MNTs (TiO 2 nanotubes). Furthermore, the effect of AMOT130 was investigated by inhibiting F-actin formation and activating AMOT130.

2024年5月17日 · Our study highlights the Hippo pathway as a pivotal regulator of BMSC multipotency, and our regulatory network inferences are a reservoir of testable hypotheses that link transcription factors and their regulons to specific aspects of BMSC behavior.

2018年6月1日 · Expression of β-catenin in YAP-deficient BMSCs (bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis.

2023年12月21日 · LWDH上调OVX-BMSCs中自噬相关蛋白LC3、Beclin1和YAP的表达，下调p62的表达。 结论：该研究 首次证明YAP诱导的自噬改变是LWDH延缓OVX中骨髓间充质干细胞衰老的关键因素 。