2018年7月23日 · We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and cholecystokinin, CCK). To...

2022年4月27日 · Electrophysiology demonstrated that chronic pain increased inhibitory inputs to lateral hypothalamus (LH)–projecting BNST neurons. Chemogenetic manipulation revealed that sustained suppression of LH-projecting BNST neurons played a crucial role in chronic pain–induced anxiety.

2019年6月24日 · Our experiments also reveal that these neurons inhibit LH-projecting neurons in ventrolateral BNST, which antagonize the anorexic effect of activating ovBNST PKC-δ neurons.

2023年4月27日 · 光激活由VGAT（vesicular GABA transporter, VGAT）标记的BNST神经元到 外侧下丘脑 （lateral hypothalamus, LH）这条重要的摄食 神经通路 ，也能诱导摄食【15】。 此外，在BNST的药理学研究以及 解剖学研究 中也表明，BNST亚区的神经元在应激或其他条件下的摄食调节中可能发挥 ...

2021年8月9日 · In this sense, the lateral hypothalamus (LH) is involved in stress responses, and BNST GABAergic neurons densely innervate this hypothalamic nucleus. However, a role of BNST projections to the LH...

2013年9月27日 · We targeted a Cre-inducible viral construct coding for Channelrhodopsin-2 fused to enhanced yellow fluorescent protein (ChR2-eYFP) into the BNST of Vgat-ires-Cre mice and positioned optical fibers above the LH for in vivo photostimulation of VgatBNST→LH projection fibers (Fig. 1, A to E, and fig. S1).

2019年7月16日 · Here, we discover that suppressing the activity of GABAergic cells in the anterior ventrolateral periaqueductal gray (vlPAG), whether directly or through long-projection GABAergic inputs from either the bed nucleus of the stria terminalis (BNST) or the lateral hypothalamus (LH), is sufficient to promptly induce feeding behavior in well-fed mice.

Here we identified inputs onto LH neurons that originate from neuronal populations in the bed nuclei of stria terminalis (BNST; a heterogeneous region of extended amygdala). We characterized two non-overlapping LH-projecting GABAergic BNST subpopulations that express distinct neuropeptides (corticotropin-releasing factor, CRF, and ...

2019年7月16日 · Here, we discover that suppressing the activity of GABAergic cells in the anterior ventrolateral periaqueductal gray (vlPAG), whether directly or through long-projection GABAergic inputs from either the bed nucleus of the stria terminalis (BNST) or the lateral hypothalamus (LH), is sufficient to promptly induce feeding behavior in well-fed mice.

bnst被认为是hpa轴活性的关键调节剂，尤其是前腹侧bnst已被证明对hpa轴起抑制性制动作用。 那么，PVHCrh神经元的GABA能输入的来源是否是BNST？ 研究人员发现，末端抑制BNSTvGAT→PVH神经元会强烈刺激血浆皮质酮水平[Fig.4i]。