Vitamin D receptor expression in human bone tissue and dose …
The present study provides immunohistochemical evidence in human bone tissue that osteoclasts express VDR, possibly for metabolism of 25(OH)D 3 as well as being responsive to 1,25(OH) …
Mechanisms involved in bone resorption regulated by vitamin D
2018年3月1日 · Active forms of vitamin D enhance osteoclastogenesis in vitro and in vivo through the vitamin D receptor (VDR) in osteoblast-lineage cells consisting of osteoblasts and …
Role of the Vitamin D Receptor (VDR) in the Pathogenesis of
2023年2月21日 · The vitamin D receptor (VDR) regulates bone development and calcium homeostasis, suggesting a central role in musculoskeletal diseases such as osteoporosis …
Modulation of the vitamin D/vitamin D receptor system in …
2023年11月13日 · The VDR is a key regulator of bone metabolism, mediating the effects of VD on calcium absorption, bone mineralization, and bone remodeling. Genetic variations in the VDR …
Coactivator-independent vitamin D receptor signaling causes …
2024年8月20日 · In humans, mutations in the AF2 domain are associated with hereditary vitamin D-resistant rickets, a genetic disorder characterized by impaired bone mineralization and …
Vitamin D receptor in osteoblast lineage cells mediates increased ...
For the treatment of both iatrogenic and endogenous hypervitaminosis D, our data suggest that VDR in osteoblast lineage cells may be a promising drug target to improve systemic …
Multiomics profiling reveals VDR as a central regulator of ... - Nature
2024年5月22日 · Our study shows that exposure to an HFD induces premature senescence in bone marrow mesenchymal stem cells (BMSCs), diminishing their proliferation and osteogenic …
VDR in Osteoblast-Lineage Cells Primarily Mediates Vitamin D ... - PubMed
Here, we examined the effects of 4-week treatment with ELD (50 ng/kg/day) on bone using osteoblast lineage-specific VDR conditional knockout (Ob-VDR-cKO) and osteoclast-specific …
Vitamin D Receptor gene (VDR) transcripts in bone, cartilage, …
2012年12月23日 · After binding to its nuclear receptor VDR, the complex 1,25-Dihydroxyvitamin D3 – VDR can influence bone metabolism indirectly by promoting intestinal absorption of …
Vitamin D receptor expression in human bone tissue and dose
2016年10月11日 · Finding that resorbing osteoclasts in human bone express vitamin D receptor (VDR), we examined their response to different concentrations of 25-hydroxy vitamin D3 …