2002年8月23日 · The TNF-like ligand BAFF/BLyS is a potent survival factor for B cells. It binds three receptors: TACI, BCMA, and BR3. We show that BR3 signaling promotes processing of the transcription factor NF-κB2/p100 to p52. NF-κB2/p100 cleavage was abrogated in B cells from A/WySnJ mice possessing a mutant BR3 gene, but not in TACI or BCMA null B cells.

2006年11月1日 · In order to investigate the consequences of targeting BR3 in murine models and to assess the potential of BR3 antibodies as human therapeutics, synthetic antibody phage libraries were employed to identify BAFF-blocking antibodies cross-reactive to murine and human BR3, which share 52% identity in their extracellular domains.

2007年12月1日 · Based on the demonstrated synergy between B-cell depletion and blockade of B-cell survival through BR3, we developed anti-BR3 antibodies that combine, in one molecule, the abilities to deplete B cells and to block BAFF-mediated B-cell survival.

Antibody-neutralizing titers of TW1, TW2, and BR3 plasma against autologous and heterologous viruses.

Antibody-neutralizing titers of BR3 plasma against TW1 viruses were similar to TW2 viruses. All time points refer to the twins infection; BR3 was infected with the twins' virus ∼13 mo later.

BAFF Receptor (B-cell activating factor receptor, BAFF-R), also known as TNFRSF13C and BR3, is a membrane protein of the TNF receptor superfamily which recognizes BAFF. BAFF Receptor is the crucial receptor for B-cell survival and also is …

2007年12月1日 · Based on the demonstrated synergy between B-cell depletion and blockade of B-cell survival through BR3, we developed anti-BR3 antibodies that combine, in one molecule, the abilities to deplete B cells and to block BAFF-mediated B-cell survival.

2001年10月2日 · Here we report the identification of a third BLyS receptor (BR3; BLyS receptor 3). This receptor is unique in that, in contrast to TACI and BCMA, BR3 only binds BLyS. Treatment of antigen-challenged mice with BR3-Fc inhibited antibody production, indicating an essential role for BLyS, but not APRIL, in this response.

2003年5月2日 · The crystal structure of the minimal hairpin peptide, bhpBR3, in complex with BAFF reveals intimate packing of the six-residue BR3 turn into a cavity on the ligand surface. Thus, BR3 binds BAFF through a highly focused interaction site, unprecedented in …

1992年5月1日 · Geometric enantiomerism in cyclic compounds: Chiral dibrominated 1,3-dioxanes.