2003年12月1日 · Intravenously administered amiodarone causes heart block or bradycardia in 4.9 percent of patients and hypotension in 16 percent. 2 If these conditions occur, infusion of the drug should be ...

Amiodarone has multiple effects on myocardial depolarization and repolarization that make it an extremely effective antiarrhythmic drug. Its primary effect is to block the potassium channels, but it can also block sodium and calcium channels and the beta and alpha adrenergic receptors.

In general practice, amiodarone can be administered to patients with bradycardia; however, it's not without risks. The drug itself may exacerbate bradycardia due to its effects on cardiac conduction. For patients already experiencing a slow heart rate, …

2023年11月12日 · The existing literature on toxicity resulting from acute amiodarone overdose predominantly highlights cardiovascular adverse effects, including hypotension, bradycardia, VT, and TdP. However, it is noteworthy that these adverse effects can also manifest at …

Amiodarone could impair sinus beat formation and conduction and may induce significant bradycardia, especially in patients with pre-existing conduction disorders, and marked prolongation of the QT interval.

2005年11月28日 · Evidence in support of amiodarone comes from 3 observational studies (LOE 5) 28–30 that indicate that amiodarone is effective for the termination of shock-resistant or drug-refractory VT. One randomized parallel study (LOE 2) 31 indicated that aqueous amiodarone is more effective than lidocaine in the treatment of shock-resistant VT.

Amiodarone caused symptomatic bradycardia in 6 of the group 1 patients (II degrees-III degrees AV block in 3 patients with preexisting I degree AV block or right bundle branch block; intermittent sinus arrest or SA block in the 3 cases with previous sinus node dysfunction). 45 patients had no conduction disorders before the administration of ...

Concomitant use with amiodarone may cause sinus bradycardia or AV block. The presence of bradycardia is notably linked to the use of amiodarone and any medication aimed at controlling heart rate. Among individuals on amiodarone, bradycardia is most strongly correlated with the use of rate-controlling medications and being female .

2024年10月11日 · Amiodarone can exacerbate arrhythmias. Initiate in a clinical setting where continuous electrocardiograms and cardiac resuscitation are available. Along with its needed effects, amiodarone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Amiodarone use and the use of any rate-controlling medication of beta-blocker, calcium channel-blocker, or digoxin were associated with bradycardia.5 In another report of patients undergoing drug trials for AF, bradyarrhythmia was the most common manifestation of proarrhythmia, occurring in 7.9% of the drug trials.3 Among the bradyarrhythmias ...