2024年1月4日 · Trajectory analysis of combined blood neutrophils and brain granulocytes indicated similarities between Gran1, which is the major Sham brain granulocyte cluster, and Neu1, Neu2 and Neu4,...

2018年11月1日 · We follow the exciting new evidence that macrophages and in particular neutrophil granulocytes can transfer inflammatory information to the brain and modulate brain function in the frame of homeostasis and pathophysiology.

2018年8月2日 · Microglia are the innate immune cells resident in the brain parenchyma. Macrophages surround the blood vessels and also line the leptomeninges and the choroid plexus together with dendritic cells and lymphocytes, among other immune cells, where they play immunosurveillance functions.

2017年7月1日 · How are neutrophil granulocytes being attracted to the site of injury and what are their tasks within the inflamed brain tissue and periphery? What are the new findings regarding the interaction of neutrophil granulocytes with microglia, immigrating haematogenous monocytes, macrophages and T cells?

2023年5月15日 · In elderly patients with ischemic stroke, single-cell proteome profile of blood leukocytes identified CD62L lo neutrophil subsets associated with worse reperfusion and outcome. Our results unveil...

In mice, inhibition of CXCL3 signaling and rejuvenation of bone marrow offer ways of restricting brain injury and improving stroke outcomes.

2018年8月9日 · Our study suggests that CD163 + macrophages attract granulocytes to the leptomeningeal and perivascular spaces in response to brain ischemia. These findings are in consonance with a study showing that perivascular macrophage depletion reduced brain neutrophil infiltration in a model of vesicular stomatitis viral infection [ 51 ].

2018年11月1日 · A particular focus is laid on the role of neutrophil granulocytes. As such, IL-1β expressing neutrophil granulocytes have been shown to transfer inflammatory information to the brain and contribute to prolonged behavioural changes due to septic encephalopathy in rats during severe systemic inflammation induced by the bacterial component and ...

Neutrophil granulocytes (or polymorphonuclear cells, PMNs) have long been considered as crude killing machines, particularly trained to attack bacterial or fungal pathogens in wounds or infected tissues. That perspective has fundamentally changed over the last decades, as PMNs have been shown to exe …

2018年8月27日 · In this review, we discuss recent findings from our lab and others that suggest possible functions for neutrophils and the neutrophil granule proteins, CAP37, neutrophil elastase, and cathepsin G, in neuroinflammation, with an emphasis on AD.