2023年3月11日 · ntcp是一种主要在肝细胞基底外侧膜表达的多跨膜糖蛋白，将结合胆汁酸从门静脉转运到肝细胞，并维持体内胆汁酸的稳态[10]。 现有研究认为，编码NTCP的基因突变并不影响体内胆盐平衡，因NTCP转运功能受损时，在肝细胞基底膜上表达的OATPs能在一定程度上代偿 ...

2022年10月17日 · ntcp 主要分布在肝脏细胞的基底膜上,由位于人14 号染色体上的slc10a1 基因编码,是一个协同转运体,它利用钠的浓度梯度将门静脉中的胆汁酸(特别是结合型牛磺胆汁酸)转运进入肝脏细胞,参与胆汁酸的肠肝循环过程｡除胆汁外,ntcp 还可以转运类固醇激素和多种药物 ...

Sodium-taurocholate cotransporting polypeptide (Ntcp) and bile salt export pump (Bsep) are two key transporters for hepatic bile acid uptake and excretion. Alterations in Ntcp and Bsep expression have been reported in pathophysiological conditions.

2022年6月20日 · NTCP was originally cloned from rat and demonstrated to be localized in the basolateral membrane. 1 Its activity is a key component of bile acid homeostasis and enterohepatic circulation of bile...

2021年8月1日 · NTCP plays a pivotal role in hepatic bile salt uptake and as the HBV/HDV viral entry receptor. Pharmacological inhibition of NTCP activity provides protection in certain cholestatic and metabolic conditions in mice and has recently been approved as …

Background: Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts. They have emerged as …

钠离子/牛磺胆酸共转运蛋白(sodium taurocholate cotransporting polypeptide, Ntcp)和胆盐输出泵(bile salt export pump, Bsep)是肝脏最重要的两个胆汁酸转运体，Ntcp主要负责将肝血窦中的胆汁酸转运到肝细胞内，Bsep将其从肝细胞转运到胆管中，两者协同参与胆汁酸的肝肠循环 ...

Regulation of NTCP copes with changes of bile salt load to hepatocytes and prevents entry of cytotoxic bile salts during liver disease. Canalicular export of bile salts is mediated by the ATP-binding cassette transporter bile salt export pump BSEP (ABCB11).

2007年12月3日 · Sodium-taurocholate cotransporting polypeptide (Ntcp) and bile salt export pump (Bsep) are two key transporters for hepatic bile acid uptake and excretion. Alterations in Ntcp and Bsep expression have been reported in pathophysiological conditions.

2007年12月3日 · Sodium-taurocholate cotransporting polypeptide (Ntcp) and bile salt export pump (Bsep) are two key transporters for hepatic bile acid uptake and excretion. Alterations in Ntcp and Bsep expression have been reported in pathophysiological conditions.