In the United States, daptomycin is indicated for use in adults for skin and skin structure infections caused by Gram-positive i… 展开

Common adverse drug reactions associated with daptomycin therapy include:
• Cardiovascular: low blood pressure, high blood pressure, swelling
• Central nervous system: insomnia… 展开

Daptomycin has a distinct mechanism of action, disrupting multiple aspects of bacterial cell membrane function. It inserts into the cell membrane in a phosphatidylglycerol-dependent fashion, where it then ag… 展开

Daptomycin is bactericidal against Gram-positive bacteria only. It has proven in vitro activity against enterococci (including glycopeptide-resistant enterococci (GRE)), staphylococci (including methicillin-resistant Staphylococcus … 展开

Daptomycin resistance is still uncommon, but has been increasingly reported in GRE, starting in Korea in 2005, in Europe in 2010, in Taiwan 2011, and in the United States, where nine cases have been reported from 20… 展开