牛病毒性腹泻-粘膜病（Bovine viral diarrhea mucosal disease，简称BVD-MD）又称牛病毒性腹泻病，是由牛病毒性腹泻粘膜病病毒 （Bovine viral diarrhea mucosal disease virus，简称BVD-MDV）引起、发生在牛身上的一种病害。 病牛主要特征为发热、粘膜糜烂溃疡、白细胞减少、腹泻免疫耐受与持续感染免疫抑制、先天性缺陷、咳嗽、怀孕母牛流产、产死胎或畸形胎。 [1] 牛病毒性腹泻-粘膜病是一种病毒性传染病，各种年龄的牛都易感，而以幼龄牛易感性最高、病牛 …

Bovine viral diarrhea (BVD), bovine viral diarrhoea (UK English) or mucosal disease, previously referred to as bovine virus diarrhea (BVD), is an economically significant disease of cattle that is found in the majority of countries throughout the world. [1] .

牛病毒性腹泻病毒 (bovine viral diarrhea virus, BVDV)主要感染牛，孕期母畜感染BVDV可引起新生动物持续性感染 (persistent infection, PI)，产生免疫耐受 [1]。 PI动物血清抗体呈阴性但终身向外排毒，是BVDV最重要的传染源。 BVDV是单股正链RNA病毒，属于黄病毒科、瘟病毒属。 根据BVDV基因遗传多样性以及抗原差异分析可将其分三大类，即BVDV-1、BVDV-2和BVDV-3 (HoBi-like virus) [2 - 3]。

Bovine Viral Diarrhea (BVD) is a disease of cattle caused by the Bovine Viral Diarrhea Virus (BVDV). The virus is widespread, and most herds are at risk for infection. In the susceptible herd, BVD can be a serious, costly disease. The signs of BVD vary, depending on the immune status of the exposed animals, and the strain of the infecting virus.

Control of bovine viral diarrhea virus (BVDV) in cattle populations across most of the world has remained elusive in spite of advances in knowledge about this viral pathogen. A central feature of virus perseverance in cattle herds is the unique mechanism of persistent infection.

The bovine viral diarrhea virus (BVDV-1) is a pathogen with the capacity to modulate the interferon type I system. To further investigate the effects of BVDV-1 on the production of the immune response, the Madin-Darby bovine kidney cell line was infected with the cytopathic CH001 field isolate of BV …

2024年5月3日 · Bovine viral diarrhea virus (BVDV) is considered to be the most common agent of severe diarrhea in cattle worldwide, causing fever, diarrhea, ulcers, and...

2025年1月10日 · Studies on the genetic characterisation of pestiviruses in Turkey reveal that the BVDV-1 genotype, particularly subtype BVDV-1l, is dominant (Yeşilbağ et al. 2008; Oğuzoğlu et al. 2012; Timurkan and Aydın 2019). Globally, BVDV-1b is the most common subtype, followed by 1a and 1c (Yeşilbağ, Alpay, and Becher 2017; Zhou et al. 2022).

2024年7月2日 · 全基因组系统发育分析是一种最适合用于牛病毒性腹泻病毒1（bvdv-1）和bvdv-2分型的策略，但对许多实验室来说是不可行的。 因此，通常根据单基因组区域（主要是5'非翻译区 (UTR)）的分析来对BVDV分离株/毒株进行分型。

The viral genotypes are termed BVDV type 1 and BVDV type 2, and both cytopathic and noncytopathic BVDV are represented in each viral genotype. In recent years, a new group of atypical pestiviruses, apparently forming a separate species, of which cattle are the most likely host species, have been recognized.