2005年3月11日 · Here we show that BZR1 is a transcriptional repressor that has a previously unknown DNA binding domain and binds directly to the promoters of feedback-regulated BR biosynthetic genes.

2021年8月15日 · 该研究还利用了kaede荧光蛋白标签来回答BR是否能够招募胞质中的BZR1入核，以及BZR1的降解是否受BR调节等科学问题。 Kaede是一种可转换荧光蛋白，正常条件下在488 nm激发光下发出绿色荧光 (Kaedegreen)。 紫外光 (390-405 nm) 的照射会导致Kaede蛋白发生不可逆的裂解，裂解后的Kaede蛋白的激发光转变为543 nm，发射光由绿色转变为红色 (Kaedered)。 因此利用 Kaede标签可以有效区分 UV 处理后新合成的 BZR1-Kaedegreen 蛋 …

BZR1 protein accumulates in the nucleus of elongating cells of dark-grown hypocotyls and is stabilized by BR signaling and the bzr1-1D mutation. Our results demonstrate that BZR1 is a positive regulator of the BR signaling pathway that mediates both downstream BR responses and feedback regulation of BR biosynthesis.

2005年3月11日 · Here we show that BZR1 is a transcriptional repressor that has a previously unknown DNA binding domain and binds directly to the promoters of feedback-regulated BR biosynthetic genes.

2025年3月1日 · Brassinosteroids (BR) are ubiquitous polyhydroxylated steroid hormones in plants that play a pivotal role in orchestrating plant growth, development, and stress mitigation. The transcription factor BRI1 EMS SUPPRESSOR 1/BRASSINAZOLE RESISTANT 1 (BES1/BZR1) is central to BR signal transduction.

2024年2月20日 · 油菜素内酯通过一系列信号级联反应，将信号传递给下游转录因子BRASSINAZOLE-RESISTANT 1 (BZR1)，进而调控BR响应基因的转录。 早在2005年，油菜素内酯和转录因子BZR1就被报道既可以抑制基因转录也可以激活基因转录。 BZR1可通过与TOPLESS相互作用进而招募Histone deacetylase 19形成转录抑制复合体抑制BR响应基因的表达，因而BZR1抑制基因转录的机制已较为清楚，但BZR1激活BR响应基因表达的分子机制仍不 …

2022年8月8日 · Nine BZR1 genes were identified in the celery genome, and categorized into four classes based on phylogenetic and gene structure analyses. All the BZR1 proteins shared a typical bHLH (basic helix-loop-helix) domain that is highly conserved across the whole family in Arabidopsis, grape, lettuce, ginseng, and three Apiaceae species.

2018年10月1日 · The authors report the non-canonical crystal structure of the DNA binding domain from BIL1/BZR1, a transcription factor involved in brassinosteroid signalling, in complex with its target DNA...

2002年4月1日 · BZR1 protein accumulates in the nucleus of elongating cells of dark-grown hypocotyls and is stabilized by BR signaling and the bzr1-1D mutation. Our results demonstrate that BZR1 is a positive regulator of the BR signaling pathway that mediates both downstream BR responses and feedback regulation of BR biosynthesis.

转录因子bes1/bzr1(bri1 ems suppressor 1/brassinazole resistant 1)是br信号转导的核心成员,被br信号激活后,结合到下游靶基因启动子区的e框(canntg)或brre元件(cgtgt/cg),调节靶基因表达。