2000年3月6日 · The c-Abl tyrosine kinase and its transforming variants have been implicated in tumorigenesis and in many important cellular processes. c-Abl is localized in the nucleus and the cytoplasm,...

c-Abl is a key regulator of many essential cell functions, and its activity is tightly controlled. It exists in a minimally active state at basal level and its overactivation is an important driver of oncogenesis in CML and ALL.

Here, we summarize recent findings on the involvement of c-Abl in normal and abnormal processes in nervous tissue, focusing on neurons, astrocytes and microglial cells, with particular reference to molecular events at the interface between stress signaling, DNA damage, and metabolic regulation.

Overexpression of active c-Abl in adult mouse neurons results in neurodegeneration and neuroinflammation. Based on this evidence, a potential role for c-Abl in the pathogenesis of neurodegenerative disease is discussed, and we attempt to place activation of c-Abl in context with other known contributors to neurodegenerative pathology.

非受体型酪氨酸激酶c-Abl具有多种生物学功能，可参与细胞周期、细胞迁移、细胞凋亡、DNA应激损伤反应修复等重要生命过程的调控，其过度激活与慢性粒细胞白血病的发生、发展密切相关，且在白血病方面的研究详细深入，但在实体瘤研究方面则刚刚起步 ...

非受体酪氨酸激酶 c-Abl (ABL1) 是细胞内和细胞外信号的关键信号转导器，它在细胞质和细胞核之间穿梭。 这篇综述的重点是 c-Abl 及其突触和神经元功能。

2004年1月1日 · The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr–Abl fusion protein, causes certain human leukaemias.

Recent studies have shown c-Abl activation in human Alzheimer's and Parkinson's diseases and c-Abl activation in mouse models and neuronal culture in response to amyloid beta fibrils and oxidative stress. Overexpression of active c-Abl in adult mouse neurons results in neurodegeneration and neuroinflammation.

The c-Abl tyrosine kinase and its transforming variants have been implicated in tumorigenesis and in many important cellular processes. c-Abl is localized in the nucleus and the cytoplasm, where it plays distinct roles. The effects of c-Abl are mediated by multiple protein-protein and …

2003年8月5日 · c-Abl is a non-receptor tyrosine kinase whose activity is tightly controlled in vivo through unknown mechanisms. Recent studies suggest that c-Abl may be regulated in different cellular contexts by distinct lipids.