C12-200: A branched-chain ionizable cationic lipidoid. CAS Number: 1220890-25-4. Purity: ≥95%.

C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200.

C12-200 is a branched-chain ionizable lipidoid with five hydroxyl groups. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA).

C12-200 Lipid (CAS: 1220890-25-4) is a branched ionizable lipid used in lipid nanoparticle (LNP) formulations. It enhances the delivery of small molecule drugs, proteins, and nucleic acids, with a notable 7-fold increase in efficacy for erythropoietin-mRNA-loaded nanoparticles.

C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation …

CordenPharma produces lipid product C12-200 - CAS# 1220890-25-4 - Item # LP-D4-476 - MW 1136.96.

C12-200. CAS 1220890-25-4. Molecular Weight 1136.95. Browse C12-200 and related products at Merck.

C12-200 Catalog No: APS-LP-CAT-07 CAS no: 1220890-25-4 Molecular Formula: C 70 H 145 N 5 O 5 Molecular Weight: 1136.96 Type: Cationic/Ionizable Purity: > 98 % by HPLC-CAD Storage: -20 degrees Solubility: Ethanol, DMSO, DMF

C12-200 is useful for Development of Lipidoid Nanoparticles for siRNA, mRNA, and vaccine Delivery. C12-200 formulation can increase the potency of erythropoietin-mRNA-loaded C12-200 lipid nanoparticles 7-fold relative to formulations previously used for siRNA delivery.

(S)-C12-200 is an ionizable cationic lipid (p Ka = 7.12) and an isomer of C12-200 (Item No. 36699). 1 It has been used in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.