2024年12月24日 · C1QBP (Complement C1q Binding Protein) is a Protein Coding gene. Diseases associated with C1QBP include Combined Oxidative Phosphorylation Deficiency 33 and Chanarin-Dorfman Syndrome. Among its related pathways are Signaling by Rho GTPases and Intrinsic Pathway for Apoptosis.

The crystal structure of C1QBP at 2.25 Å resolution shows a homotrimeric ring displaying symmetry.The individual subunits are held together by noncovalent interactions and forms a doughnut shaped quaternary structure with a central cavity of 20 Å in diameter. Each Subunit of C1QBP has seven β-strand (β1- β7) and three α-helices (α1- α3). C1QBP is negatively charged on its soluble face ...

2021年12月4日 · C1qbp（补体C1q结合蛋白，又称为p32或gC1qR）是一种已知的对线粒体氧化磷酸化很重要的多功能蛋白，能通过结合RNA的方式促进线粒体基因编码蛋白的翻译。

2019年3月14日 · Complement component 1q subcomponent binding protein (C1qbp) is a multifunctional protein involved in immune response, energy homeostasis of cells as a...

人补体亚成分 C1q 与 C1r 和 C1s 结合，以产生血清补体系统的第一个成分。 已知由该基因编码的蛋白质与 C1q 分子的球状头部结合并抑制 C1 激活。 该蛋白还被鉴定为前体 mRNA 剪接因子 SF2 的 p32 亚基，以及透明质酸结合蛋白。 [RefSeq 提供，2008 年 7 月] The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum Complement System.

2025年2月9日 · C1qbp is upregulated in human lung and colon cancer cell lines and tumors. Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway.

Complement C1q binding protein (C1QBP, p32) is primarily localized in mitochondrial matrix and associated with mitochondrial oxidative phosphorylative function. C1QBP deficiency presents as a mitochondrial disorder involving multiple organ systems.

2025年2月8日 · Mitochondrial C1QBP is essential for T cell antitumor function by maintaining mitochondrial plasticity and metabolic fitness. Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.

2024年12月29日 · 本文将详细介绍c1qbp基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面理解这一基因在生物体中的重要作用。 C1QBP基因的功能 C1QBP基因，也被称为gC1Q-R、gC1qR、p32或SF2p32，位于染色体17p13.2。

人类补体亚成分C1q与C1r和C1s结合，以产生血清补体系统的第一成分。 这个基因编码的蛋白质已知可以与C1q分子的球形头部结合并抑制C1的激活。 这个蛋白质还被鉴定为pre-mRNA剪接因子SF2的p32亚基，以及一种透明质酸结合蛋白质。 [由RefSeq，2008年7月提供] Dir./Indir. Functional annotation of a full-length mouse cDNA collection. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.