Glia-Selective Deletion of Complement C1q Prevents Radiation-Induced ...
2021年4月1日 · The underlying alterations in CNS complement cascade proteins (C1q, C3), TLR4, and colabeling with glia (IBA1, GFAP) were examined using gene expression, …
Complement C3 Is Activated in Human AD Brain and Is Required …
2019年8月20日 · We find that C3 protein accumulates in synapses in human AD brains with tau pathology. Furthermore, intact and processed C3 levels are increased in cerebrospinal fluid …
Complement C3 knockout protects photoreceptors in the sodium …
2025年1月1日 · In the RC (Fig. S1B), levels of Hif1α, C1q, and Iba1 were significantly elevated in both NaIO 3-treated groups, with no reduction in upregulation observed in the C3 knockout …
The endogenous neuronal complement inhibitor SRPX2 protects …
2020年7月13日 · Here, we show that the sushi domain protein SRPX2 is a neuronally expressed complement inhibitor that regulates complement-dependent synapse elimination. SRPX2 …
阿尔茨海默病中的小胶和星胶通过补体C1q依赖途径协调清除突触@…
2022年11月17日 · 近期，《Nature Aging》期刊发表了题为“Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's …
Synthesis and Propagation of Complement C3 by …
C3 staining (A, D, arrows) was found to correlate strongly with IBA1-immunoreactive microglia/monocytes (B, E, arrows), which were in close association with both superficial and …
Astrocyte-neuron communication through the complement C3 …
2025年1月1日 · Complement C3 was significantly colocalized with GFAP in both the striatum (Fig. S1 a) and SN (Fig. 1 d), while no significant colocalization was observed with IBA1 or NEUN …
Complement C1q-dependent excitatory and inhibitory synapse
2022年9月20日 · Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial …
C3/C3aR Bridges Spinal Astrocyte‐Microglia Crosstalk and …
2025年1月13日 · Our results showed that in the spinal dorsal horn of morphine-tolerant rats, C3 could be colocalized with GFAP, NeuN (a neuronal marker) and Iba1, indicating that C3 …
Targeting CXCL16 and STAT1 augments immune checkpoint …
2023年4月13日 · To validate the predicted activation status of STAT1 regulon after MCT treatment, we co-stained C3-1-TAg and MMTV-PyMT tumors with Iba1 (myeloid marker) and …