Structures of complement component C3 provide insights into …
2005年9月22日 · Activation of component C3 (1,641 residues) is central to the three complement pathways and results in inflammation and elimination of self and non-self targets. Here we …
TLQP-21 mediated activation of microglial BV2 cells
2020年4月9日 · TLQP-21 increases fAβ uptake by microglial BV2 cells via C3AR1-dependent mechanisms. TLQP-21 enhances the degradation of engulfed Aβ by stimulating a lysosomal …
Complement 3a induces the synapse loss via C3aR in mitochondria ...
2024年10月1日 · Highly accumulated C3a induces the aggregation and deposition of Aβ and tau. Activating axis of C3a-C3aR impairs the mitochondria through NLRP3 inflammasomes. …
Microglia aggravate white matter injury via C3/C3aR pathway after ...
2024年9月1日 · C3a, a potent anaphylatoxin, has been shown to exert protective effects in the brain, promoting neurogenesis and limiting neuroinflammation. Evidence suggests that …
TLQP-21 mediated activation of microglial BV2 cells promotes
2020年4月9日 · TLQP-21 also improved microglial phagocytic activity and promoted fibrillar amyloid-β (fAβ) uptake by microglial BV2 cells via a C3AR1-dependent mechanism. Moreover, …
Complement C3a signaling facilitates skeletal muscle regeneration …
2017年12月12日 · Exogenous administration of recombinant CCL5 to C3aR-deficient mice rescues the defects in inflammatory cell recruitment and regeneration. These findings reveal …
Complement Protein C3 Suppresses Axon Growth and Promotes …
2017年10月10日 · Although this novel C3a result is surprising, a recent paper has suggested that C3a and C3aR positively regulate axon growth-associated protein GAP43 as well as synapsin …
Complement C3 and Activated Fragment C3a Are Involved in …
In this study, we examined the immunological properties of C3 and its activated fragment C3a from Japanese flounder (Paralichthys olivaceus) (PoC3 and PoC3a), a teleost species with …
Cell：从结构上揭示补体受体激活和信号转导耦合机制 - 知乎
补体系统是人体先天性免疫反应的重要组成部分，而 补体级联反应 （complement cascade）的最终产物---过敏毒素 C3a 和 C5a 在人体抵御有害入侵者的复杂过程中，补体系统发挥着关键作 …
补体 C3（C3）基因 | MCE - MCE-生物活性分子大师
The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic …