C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system. C3b is potent in opsonization: …

2024年8月2日 · Herein, we developed a human-derived and antibody-like C3b-targeted fusion protein (CRIg-FH-Fc) x2, termed CG001, that could potently block all 3 complement pathways. …

2022年1月1日 · Some of the most fundamental features of C3 biochemistry can be understood by examining the structures of C3, C3b, and C3c, including (i) how the α and β chains relate to …

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2009年1月20日 · Using single-particle electron microscopy we have determined the 3-dimensional structures of the C3bB and the C3bBb complexes at ≈27Å resolution. The C3bB structure …

2006年11月9日 · Here we present the crystal structure at 4-A resolution of the activated complement protein C3b and describe the conformational rearrangements of the 12 domains …

C3b is a highly unstable molecule that has a unique thioester that allows covalent binding to a microbial cell. Some C3b fragments bind to the target cell, where they act as opsonins. In the …

Here, we revealed that complement component 3 (C3) is remarkably upregulated in paclitaxel (PTX)-resistant non-small cell lung cancer (NSCLC) cells and that knockdown of C3 promoted …

2007年11月5日 · Little is known about other neisserial targets for complement proteins C3 and C4, which covalently attach to bacterial surfaces and initiate opsonization and killing. In this …

向培养的神经元中添加纯化的C3裂解产物表明C3b负责C3的生长抑制以及神经毒性或抗粘附活性。 这些数据表明，C3在体外可减少神经突向外生长和神经元活力，并在体内限制轴突再生，并 …