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2021年7月6日 · WHAT DOES IT MEAN IF YOUR COMPLEMENT C4A RESULT IS TOO LOW? Lower-than-normal complement C4 values could indicate: – bacterial infections. – hepatitis. – malnutrition. – rejection of a kidney transplant. – systemic lupus erythematosus, which is an autoimmune disease affecting the skin, joints, kidneys, and other organs.

We are thrilled to announce the 2025 C4A Conference will be held on November 5-7, 2025, at the Hyatt Regency Orange County! 🗓️ This year’s theme, "Partnering to Prosper: Joining Allies to Protect the Future," focuses on strengthening partnerships, building collaborations, and making lasting changes that will impact the lives of older ...

Complement C4-A is a kind of the Complement component 4 protein that in humans is encoded by the C4A gene. [5] This gene encodes the acidic form of complement factor 4, part of the classical activation pathway.

C4A works with community partners and statewide allies to educate the public, elected officials, and other government leaders about aging and disability-related policy and funding issues, and to advocate for solutions to those issues.

Complement cascade activation results in the formation of complement split products C 3 a, C 4 a, and C 5 a. 4 These proteins, referred to as anaphylatoxins, facilitate the phagocytosis of immune complexes, viral particles, toxic cell debris and apoptotic corpses.

2024年12月24日 · C4A (Complement C4A (Chido/Rodgers Blood Group)) is a Protein Coding gene. Diseases associated with C4A include Complement Component 4A Deficiency and Blood Group, Chido/Rodgers System.

Complement C4a or complement component 4a is a glycoprotein and peptide that is expressed, primarily in the liver and in macrophages, in response to acute inflammation or tissue injury. Complement C4a is part of the Complement C4 family.

Combined with the absence of an identified C4a receptor and the inability of C4a to signal through the C3a and C5a receptors, it is clear that C4a should not be included in the family of complement anaphylatoxins. Key Words: Anaphylatoxin, Complement, G-protein-coupled receptors.

Gene ID: 720, updated on 8-Feb-2025. This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion.