1243243-89-1 | CAS数据库 - ChemicalBook
Mar 7, 2025 · Wnt-C59 (C59)是一种PORCN抑制剂，作用于Wnt3A介导的多聚TCF结合位点驱动的荧光素酶的激活，在 HEK293细胞中IC50为74 pM。 Wnt-C59 (C59)在纳摩尔浓度时抑制PORCN酶活性。 Wnt-C59 (10 nM)作用于转染WNT3A-V5或WNT8A-V5质粒的HeLa细胞，抑制Palmitoylation依赖性的Wnt-WLS互动。 Wnt-C59 (100 nM)作用于转染WNT3A-V5的HeLa细胞，抑制Palmitate合并到WNT3A，与此一致的是，PORCN活性受抑制。 Wnt-C59 (100 nM)作 …
Wnt-C59 (C59) | 99.99% (HPLC) | In Stock | PORCN inhibitor
May 22, 2024 · Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM in HEK293 cells. Wnt-C59 (C59) is claimed to inhibit PORCN enzyme activity at nanomolar concentrations.
- Reviews: 157
Wnt-C59, Wnt 拮抗剂, Wnt 信号通路抑制剂 - 知乎 - 知乎专栏
Wnt-C59 是一种 PORCN 的强效 抑制剂，通过阻止 Wnt3A 活化来测量 (IC50 = 74 pM)。 由于 Wnt 的分泌需要 棕榈酰化，Wnt-C59 完全阻断 Wnt3A 分泌到培养基中。 Wnt-C59 是一种 PORCN 的强效抑制剂，通过阻止 Wnt3A 活化来测量 (IC50 = 74 pM)。 由于 Wnt 的分泌需要棕榈酰化，Wnt-C59 完全阻断 Wnt3A 分泌到培养基中。 图1.Wnt-C59化学结构 Wnt-C59基础信息中文名：Wnt-C59;…
Wnt-C59 | 1243243-89-1 - ChemicalBook
Jan 27, 2025 · Wnt-C59 (1243243-89-1) is a potent (IC50 = 74 pmol/L) inhibitor of Porcupine (PORCN), a Wnt-acyltransferase.1 Blockage of Wnt-acyltransferase prevents secretion of all Wnt isoforms.? It was able to block progression of mammary tumors in MMTV-WNT1 transgenic mice.1? Wnt-C59 strongly inhibited the growth of intestinal neoplasia in RZ-mutant mice.2?
Wnt-C59 (Wnt-C59) - 药物靶点：PORCN_在研适应症：肿瘤_专利_ …
Wnt-C59: 一种PORCN抑制剂药物，由Duke-NUS Graduate Medical School Singapore (Duke-NUS Graduate Medical School Singapore)公司最早进行研发，目前全球最高研发状态为临床前，作用机制: PORCN抑制剂 (PorcupineO-酰基转移酶抑制剂)，治疗领域: 肿瘤，在研适应症: 肿瘤，在研机构: Duke-NUS ...
Wnt-C59 | PORCN Inhibitors: R&D Systems
Wnt-C59 is a highly potent inhibitor of the MBOAT (membrane-bound O-acyltranferase) family member, Porcupine (PORCN) (IC 50 = 74 pM), that mediates WNT palmitoylation and secretion. Wnt-C59 potently inhibits the processing of both canonical (1, 2, 3a, 6, 7b, 8a, 9a, 9b, 10) and non-canonical (4, 5a, 11, 16) Wnt subtypes.
- Reviews: 1
C59, Porcn Inhibitor II Sigma-Aldrich - MilliporeSigma
Porcn Inhibitor II, C59 | Wnt inhibitor | Inhibits Porcn-mediated Wnt palmitoylation. Available in 10 mg, powder, order online.
Wnt-C59 | CAS 1243243-89-1 | SCBT - Santa Cruz Biotechnology
Application: Wnt-C59 is a porcupine homolog – Drosophila (PORCN) inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase
化合物Wnt-C59，10 mM in DMSO 溶液,Wnt-C59, 10 mM in DMSO ,CAS : [1243243-89 …
Wnt-C59 (C59) 是一种高效的、口服具有活力的PORCN 抑制剂 (IC50:74 pM)。 属性
产品描述 Wnt-C59 (C59) 是PORCN 抑制剂,作用于Wnt3A- 调节的多聚TCF结合位点驱动的荧光素酶的激活,IC. 体外研究 Wnt-C59 (C59) 在纳摩尔浓度时抑制PORC. N 酶活性。Wnt-C59(10 …