Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM. Wnt-C59 (C59) inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by …

This article reports a novel differentiation method using a small-molecule WNT inhibitor, WNT-C59 (C59), to efficiently induce human anterior cortex. C59 efficiently induced CTIP2+/COUP-TF1− cells, which are characteristic of the cells found in the ...

2021年7月1日 · Wnt-C59 showed a dose-dependent anti-inflammatory effect by suppressing the expression of proinflammatory cytokines including IL6, CCL2, IL1A, IL1B, and TNF in LPS-stimulated cells. The dysregulation of the Wnt/β-catenin pathway in LPS stimulated cells was suppressed by Wnt-C59 treatment.

Wnt-C59 是一种 PORCN 的强效 抑制剂，通过阻止 Wnt3A 活化来测量 (IC50 = 74 pM)。 由于 Wnt 的分泌需要 棕榈酰化，Wnt-C59 完全阻断 Wnt3A 分泌到培养基中。 Wnt-C59 是一种 PORCN 的强效抑制剂，通过阻止 Wnt3A 活化来测量 (IC50 = 74 pM)。 由于 Wnt 的分泌需要棕榈酰化，Wnt-C59 完全阻断 Wnt3A 分泌到培养基中。 图1.Wnt-C59化学结构 Wnt-C59基础信息中文名：Wnt-C59;…

Here, we report a novel differentiation method using a small‐molecule WNT inhibitor, WNT‐C59 (C59), to efficiently induce human anterior cortex. We compared two types of small molecules, C59 and XAV939 (XAV), as substitutes for DKK1 to induce cortical neurons from PSCs in serum‐free embryoid body‐like aggregate culture.

2021年6月10日 · Wnt-C59, as a Wnt signaling inhibitor, inhibited the Wnt/β-catenin pathway, and its interaction with the NF-κB pathway, which resulted in the inhibition of NF-κB activity and proinflammatory cytokine expression. In multiple organs of endotoxemic mice, Wnt-C59 significantly reduced the β-catenin level and interaction with NF-κB.

CD59 is a 77-amino acid membrane glycoprotein that plays an important role in regulating the terminal pathway of complement by inhibiting formation of the cytolytic membrane attack complex (MAC or C5b-9).

受抑制。Wnt-C59 (100 nM) 作用于转染PORCN 质粒的HT1080 细胞抑制所有PORCN 剪接� 的活性。Wnt-C59在纳摩尔水平抑制哺乳动物PORCN 酰基转移酶活性, 且抑制所有人类W

CD59 Antibody recognizes endogenous levels of total CD59 protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln99 of human CD59 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes. Wnt-C59 has the potential to eradicate cancer stem cells in human tumors.