Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM. Wnt-C59 (C59) inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by …

This article reports a novel differentiation method using a small-molecule WNT inhibitor, WNT-C59 (C59), to efficiently induce human anterior cortex. C59 efficiently induced CTIP2+/COUP-TF1− …

Jul 1, 2021 · Wnt-C59 showed a dose-dependent anti-inflammatory effect by suppressing the expression of proinflammatory cytokines including IL6, CCL2, IL1A, IL1B, and TNF in LPS …

Wnt-C59 是一种 PORCN 的强效 抑制剂，通过阻止 Wnt3A 活化来测量 (IC50 = 74 pM)。 由于 Wnt 的分泌需要 棕榈酰化，Wnt-C59 完全阻断 Wnt3A 分泌到培养基中。 Wnt-C59 是一种 …

Here, we report a novel differentiation method using a small‐molecule WNT inhibitor, WNT‐C59 (C59), to efficiently induce human anterior cortex. We compared two types of small molecules, …

Jun 10, 2021 · Wnt-C59, as a Wnt signaling inhibitor, inhibited the Wnt/β-catenin pathway, and its interaction with the NF-κB pathway, which resulted in the inhibition of NF-κB activity and …

CD59 is a 77-amino acid membrane glycoprotein that plays an important role in regulating the terminal pathway of complement by inhibiting formation of the cytolytic membrane attack …

受抑制。Wnt-C59 (100 nM) 作用于转染PORCN 质粒的HT1080 细胞抑制所有PORCN 剪接� 的活性。Wnt-C59在纳摩尔水平抑制哺乳动物PORCN 酰基转移酶活性, 且抑制所有人类W

CD59 Antibody recognizes endogenous levels of total CD59 protein. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues …

Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes. Wnt-C59 has the potential to eradicate cancer …