The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (C luster of D ifferentiation 88) is a G protein-coupled receptor for C5a. It functions as a …

补体过敏毒素 C5a 是宿主防御的促炎成分，通过两种已识别的受体 C5a 受体 (C5aR) 和 C5L2 发挥作用。C5aR 是经典的 G 蛋白偶联受体，而 C5L2 结构同源但缺乏 G 蛋白偶联。在人类中 …

2024年12月24日 · C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Atypical Hemolytic-Uremic Syndrome and Hypersensitivity …

2018年2月13日 · Complement component fragment 5a receptor (C5aR) is one among the two chemoattractant receptors known in the rhodopsin family of G-protein coupled receptors …

2023年2月17日 · Here, we present cryo-electron microscopy structures of the activated wild-type C5aR1–G i protein complex bound to each of the following: C5a, the hexapeptidic agonist C5a …

2018年6月4日 · Targeting C5aR has emerged as a novel anti-inflammatory therapeutic method. However, developing potent C5aR antagonists as drugs has proven difficult. Here, we report …

2019年6月15日 · Complement activation generates the core effector protein C5a, a potent immune molecule that is linked to multiple inflammatory diseases. Two C5a receptors, C5aR1 …

C5a anaphylatoxin receptor (C5aR) is a G protein-coupled receptor for C5a and modulates inflammatory responses, obesity, development and cancers.

2016年2月16日 · The anaphylatoxin receptor C5aR is one of the two major G-protein coupled receptors (GPCRs) identified in the human genome that interact with the complement …

The complement anaphylatoxin C5a is a proinflammatory component of host defense that functions through two identified receptors, C5a receptor (C5aR) and C5L2. C5aR is a classical …