2004年1月30日 · We demonstrate that in primary cortical neurons, C75 inhibits FAS activity and stimulates carnitine palmitoyltransferase-1 (CPT-1), consistent with its effects in peripheral tissues. C75 alters neuronal ATP levels and AMP-activated protein kinase (AMPK) activity.

TOFA (5-tetradecyloxy-2-furoic acid) 对肺癌细胞 NCI-H460 和结肠癌细胞 HCT-8 和 HCT-15 具有细胞毒性，IC 50 约为 5.0、5.0 和分别为 4.5 μg/mL。 1.0-20.0 μg/mL 的 TOFA 以剂量依赖性方式有效阻断脂肪酸合成并诱导细胞死亡 [1] 。

2021年8月10日 · In this study, two chemical inhibitors of the fatty acid synthesis pathway [5- (tetradecyloxy)-2-furoic acid (TOFA) and tetrahydro-4-methylene-2R-octyl-5-oxo-3S-furancarboxylic acid (C75)] significantly impaired the late stage of viral propagation, suggesting CSFV replication required fatty acid synthesis.

腹腔注射后 10-24 小时，C75 阻断空腹诱导的弓状核 (Arc)、下丘脑外侧区 (LHA) 和室旁核 (PVN) 中的 c-Fos 表达。腹膜内注射 30 mg/kg 体重的 C75 后 2 小时内可抑制小鼠摄食 ≥ 95% 。由于脂肪酸氧化，C75 处理的 DIO 小鼠体重减轻了 50%，能量产生增加了 32.9%。

2008年10月24日 · TOFA, an ACC inhibitor, blocks malonyl-CoA formation, thus prevents the C75-induced accumulation of malonyl-CoA in the hypothalamus and reverses the effects of C75 (Loftus et al., 2000, Hu et al., 2003).

2006年3月1日 · In the present study using C75, cerulenin and TOFA, known fatty acid biosynthesis inhibitors, we first demonstrate the effect of feeding inhibition during Helicoverpa zea larval development. In addi tion, C75 was applied to inhibit pheromone pro duction through fatty acid synthesis in isolated pheromone gland of H zea female adults.

Consistent with this view, an inhibitor of ACC, TOFA, which should lower the rate of formation of malonyl-CoA, prevented the C75-induced increase in malonyl-CoA level and prevented the...

TOFA, an inhibitor of acetyl-CoA carboxylase, increases ATP levels, but does not affect AMPK activity. Several downstream pathways are affected by C75 treatment, including glucose metabolism and acetyl-CoA carboxyl-ase (ACC) phosphorylation. These data demonstrate that C75 modulates the levels of energy intermediates,

2003年11月1日 · C75, an inhibitor of fatty acid synthase (FAS), induces apoptosis in cultured human cancer cells. Its proposed mechanism of action linked high levels of malonyl-CoA after FAS inhibition to potential downstream effects including inhibition of carnitine palmitoyltransferase-1 (CPT-1) with resultant in …

c75是一种稳定的 fasn 抑制剂，(±)-c75 对许多人类癌细胞系也具有细胞毒性，这种作用被认为是由具有上调 fasn 途径的细胞中丙二酰辅酶 a 的积累介导的。