PKCα integrates spatiotemporally distinct Ca - Nature
2018年7月16日 · Here, we develop highly sensitive, isozyme-specific sensors for each of the classical PKCs in order to analyze Ca 2+ -dependent PKC function in plasticity. We find that classical PKCs have...
蛋白激酶C - 百度百科
PKC酶又被诸如二酰甘油（DAG）或钙离子（Ca2+）浓度增加的信号激活。 因此，PKC酶在几种信号转导级联中发挥重要作用。 在生物化学中，PKC家族由15种人类的同工酶组成。 根据其第二信使，它们被分为三个亚家族：传统型（或经型）、新型和非典型。 传统型（c）PKCs含有α、βI、βII和γ亚型。 它们需要Ca2+、DAG和磷脂例如磷脂酰丝氨酸来激活。 新型（n）PKCs包括δ、ε、η和θ亚型，需要DAG，但不需要Ca2+激活。 因此，传统型和新型PKCs通过与磷脂酶C相 …
Protein kinase C - Wikipedia
In cell biology, protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
Protein kinase C-mediated calcium signaling as the basis for ...
2021年4月15日 · PKC blockade slightly increases [Ca 2+] in and NO levels, suppressing L-type currents. Receptor-mediated PKC activation modulates Ca 2+ release through ryanodine receptor. Ca 2+ -overloaded region size determines switching of local PKC-induced signaling to global. Broad spectrum of PKC isoforms is expressed in cardiomyocytes especially α-,δ-, ε-.
Activators and Inhibitors of Protein Kinase C (PKC): Their …
Protein kinase C (PKC), a family of phospholipid-dependent serine/threonine kinase, is classed into three subfamilies based on their structural and activation characteristics: conventional or classic PKC isozymes (cPKCs; α, βI, βII, and γ), novel or ...
Dynamics and membrane interactions of protein kinase C - PMC
Protein Kinase C (PKC) is a family of Ser/Thr kinases that regulate a multitude of cellular processes through participation in the phosphoinositide signaling pathway. Significant research efforts have been directed at understanding the structure, ...
GPCR、钙、cAMP - Cell Signaling Technology (CST)
传统的 PKC 酶（cPKC；同工型 PKCα、PKCβ 和 PKCγ）包括功能性 C1 和 C2 调节结构域；要激活 cPKC 酶，需要将甘油二酯 (DAG) 和磷脂与 C1 结构域结合起来，同时将 Ca2+ 与 C2 结构域结合起来。 新 PKC 酶（nPKC；同工型 PKCδ、PKCε、PKCη 和 PKCθ）也需要 DAG 结合以进行激活，但包含不作为 Ca2+ 传感蛋白的新 C2 结构域。 最不相关的蛋白激酶 D 蛋白常与新 PKC 酶结合，因为它们会对 DAG 作出反应，但不对 Ca2+ 刺激作出反应。 非典型酶（aPKC；亚型 …
蛋白激酶C - 维基百科，自由的百科全书
蛋白激酶C （英語： Protein kinase C，简称 PKC，EC编号：2.7.11.13）是一種 蛋白质 激酶 家族，通过将其它 蛋白质 的 丝氨酸 / 苏氨酸 侧链上的 羟基 磷酸化 来调节这些蛋白的活性。 而蛋白激酶C也受 二酸甘油酯 （DAG）或 钙 离子 (Ca 2+)浓度的调控 [1]，因此蛋白激酶C在几个 信号通路 中扮演重要角色。 在人类基因组中，15个 同工酶 构成了PKC家族 [2] 。 这些同工酶可依所需 第二信使 的不同分为三类：典型或传统的PKC（classical or conventional PKC,cPKC）；新型 …
PKCα integrates spatiotemporally distinct Ca 2+ and autocrine …
The activation of PKCα during plasticity requires both NMDA receptor Ca 2+ flux and autocrine brain-derived neurotrophic factor (BDNF)-TrkB signaling, two pathways that differ vastly in their spatiotemporal scales of signaling. Our results suggest that, by integrating these signals, PKCα combines a measure of recent, nearby synaptic ...
PKC-α regulates cardiac contractility and propensity toward heart ...
2004年2月15日 · Here we identify PKC-α as a fundamental regulator of cardiac contractility and Ca 2+ handling in myocytes. Hearts of Prkca -deficient mice are hypercontractile, whereas those of transgenic mice...