CA3 pyramidal cell axons form an associative network associated with sharp waves and other EEG oscillations as well as epileptiform synchrony. Paired records from CA3 pyramidal cells and interneurons have provided data on synaptic contacts and efficacy within recurrent circuits.

2024年10月24日 · Using intracellular V m recordings and optogenetic manipulations in behaving mice, we found that CA3 place-field activity is produced by a symmetric form of behavioral timescale synaptic plasticity (BTSP) at recurrent synapses among CA3 pyramidal neurons but not at synapses from the dentate gyrus (DG).

2024年12月11日 · Combining multicellular patch-clamp recording with expansion-based superresolution microscopy and full-scale modeling, we determined the cellular and microcircuit properties of the human hippocampal CA3 region, a fundamental circuit for memory storage.

2024年10月25日 · 大量实验研究表明，海马体CA3区域的损伤会显著削弱动物在复杂情境中的记忆表现。此外，与空间记忆密切相关的位置细胞 （place cell） 序列活动，在解剖学层面最初起源于CA3。

2024年11月27日 · Using intracellular V m recordings and optogenetic manipulations in behaving mice, we found that CA3 place-field activity is produced by a symmetric form of behavioral timescale synaptic plasticity (BTSP) at recurrent synapses among CA3 pyramidal neurons but not at synapses from the dentate gyrus (DG).

2023年2月28日 · Sheintuch et al. study the three-way relationship between precision, stability, and assembly organization of hippocampal place cells. Place cells in CA3 exhibit more precise and stable tuning than in CA1 and display a stronger cell assembly organization.

2024年10月24日 · 美国贝勒医学院Jeffrey C. Magee等研究人员合作揭示海马CA3区支持记忆的神经元动态机制。 2024年10月24日，《细胞》杂志在线发表了这项成果。 通过对行为小鼠进行细胞内膜电位记录和光遗传学操作，研究人员发现CA3区的位置场活动是由CA3锥体神经元间的递归突触的行为时间尺度突触可塑性（BTSP）对称形式产生的，而在齿状回（DG）突触中并不存在。 进一步的操作揭示，从内嗅皮层（EC）而非DG的兴奋性输入是根据动物运动更新位置细胞活动 …

2017年3月2日 · The main feature of CA3 circuits is the extensive excitatory interconnections between CA3 pyramidal cells (PCs) through associational and commissural (A/C) (depending on the origin of inputs...

2021年5月20日 · To understand how spatial representations emerge and evolve across hippocampal subfields, we compared trial-to-trial dynamics of place cells in CA1 and CA3 in new environments and across days.

2024年11月27日 · Hippocampal CA3 is central to memory formation and retrieval. Although various network mechanisms have been proposed, direct evidence is lacking. Using intracellular V_m recordings and optogenetic manipulations in behaving mice, we found that CA3 place-field activity is produced by a symme …