2024年12月11日 · In contrast to neocortical networks, human hippocampal CA3 displayed sparse connectivity, providing a circuit architecture that maximizes associational power. Human synapses showed unique reliability, high precision, and long integration times, exhibiting both species- and circuit-specific properties.

2009年6月25日 · We found that posttraining blockade of CA3 output for up to 4 weeks impairs the consolidation of contextual fear memory. Moreover, in vivo hippocampal recordings revealed a reduced intrinsic frequency of CA1 ripples and a significant decrease in the experience-dependent, ripple-associated coordinated reactivation of CA1 cell pairs.

The consolidation of long-term memories requires connectivity within HPC subregions (dentate gyrus [DG], CA3, CA1) forming a trisynaptic DG–CA3–CA1 loop . Specifically, excitatory glutamatergic inputs convey experiential, sensory information into entorhinal cortex (EC), from both cortical and limbic regions, such as amygdala.

2014年7月2日 · To visualize memory traces, we created a transgenic line that allows for the comparison between cells activated during encoding and expression of a memory. Mice re-exposed to a fear-inducing context froze more and had a greater percentage of reactivated cells in the dentate gyrus (DG) and CA3 than mice exposed to a novel context.

2020年4月2日 · Age-related memory deficits were predicted by connectivity between left CA3 and hippocampal circuitry along with connectivity between left CA1 and infralimbic prefrontal cortex. Notably, the effects of CA3 connectivity on memory performance were mediated by CA1 connectivity with prefrontal cortex.

从解剖学的角度来看，海马常被看做侧脑室颞角的一个内侧凸起。它由ca1、ca2、ca3和ca4四个区域组成。

2025年1月23日 · In contrast to neocortical networks, human hippocampal CA3 displayed sparse connectivity, providing a circuit architecture that maximizes associational power. Human synapses showed unique reliability, high precision, and long integration times, exhibiting both species- and circuit-specific properties.

作者接着分析了不同物种中的单元epsps和epscs（图3f-h）。小鼠和人类ca3突触特性的直接比较显示，两个物种在突触传递的可靠性和振幅精度方面存在一个主要差异。人类ca3-ca3突触非常可靠，而小鼠突触显示出显著较低的成功率（图3g）。

2009年6月25日 · We found that posttraining blockade of CA3 output for up to 4 weeks impairs the consolidation of contextual fear memory. Moreover, in vivo hippocampal recordings revealed a reduced intrinsic frequency of CA1 ripples and a significant decrease in the experience-dependent, ripple-associated coordinated reactivation of CA1 cell pairs.

2021年5月17日 · 在 CA3 亚类中，根据多种标记基因，包括 Gal、Rgs12、Glipr1、Necab1 和 Calb2（HPF 标记）确定了一个肺门苔藓细胞超型 Mossy Rgs12。 CA1、CA3 和 SUB 沿多个维度（浅表-深、近-远端和背腹）具有逐渐的基因表达和连接性变化 。