Background and purpose Cerebral amyloid angiopathy (CAA) is common in the ageing brain and is associated with dementia and lobar intracerebral haemorrhage. We systematically reviewed genetic associations with CAA to better understand its pathogenesis.

Hereditary cerebral amyloid angiopathy is a condition characterized by an abnormal buildup of protein clumps called amyloid deposits in the blood vessels in the brain, causing vascular disease (angiopathy).

Cerebral amyloid angiopathy (CAA), which is characterized by the accumulation of amyloid fibrils in the walls of small to medium-sized arterial blood vessels, and in capillaries of the central nervous system (CNS) parenchyma and leptomeninges, is a major cause of spontaneous intracerebral haemorrhage (ICH) in elderly people and an important cont...

Background and purpose: Cerebral amyloid angiopathy (CAA) is common in the ageing brain and is associated with dementia and lobar intracerebral haemorrhage. We systematically reviewed genetic associations with CAA to better understand its pathogenesis.

Cerebral amyloid angiopathy (CAA) is a form of angiopathy in which amyloid beta peptide deposits in the walls of small to medium blood vessels of the central nervous system and meninges. [2][3] The term congophilic is sometimes used because the presence of the abnormal aggregations of amyloid can be demonstrated by microscopic examination of bra...

2024年11月23日 · Introduction: Genetics of cerebral amyloid angiopathy (CAA) remains understudied. Methods: We assessed variants in Alzheimer's disease (AD) risk factor genes and differential diagnosis genes by performing exome sequencing among 78 patients with early-onset definite or probable CAA, after negative screening for APP mutation or duplication.

2023年11月15日 · CAA is a progressive neurological condition with amyloid deposits in brain blood vessel walls. CAA is a major cause of cerebral hemorrhage and cognitive decline, particularly in individuals with AD. Missed diagnosis of CAA can have significant consequences.

2022年1月1日 · Most forms of hereditary CAA are caused by APP mutations, leading to accumulation of amyloid beta in vascular deposits within the small vessels of the central nervous system. Cognitive decline is a common manifestation of hereditary CAA, either due to recurrent hemorrhagic stroke events or as chronic progression of small vessel vasculopathy.

Cerebral amyloid angiopathy (CAA) is a common untreatable cause of lobar hemorrhages and cognitive decline in the older population. Subset of patients present with its inflammatory subtype with rapid decline in cognitive functions and neurological ...

2004年11月15日 · Hereditary forms of CAA are associated with mutations in the genes coding these proteins or their precursors. Sporadic CAA of Aβ type, the most common form of CAA, is frequently found in elderly individuals as well as patients with Alzheimer disease (AD), indicating that aging and AD are definite risk of sporadic CAA.