2023年11月12日 · Cancer-associated fibroblasts (CAFs) are mesenchymal cells in the tumor microenvironment (TME). CAFs are the most abundant cellular components in the TME of solid tumors. They affect the progression and course of chemotherapy and radiotherapy in various types of tumors including colorectal cancer (CRC).

2021年12月20日 · Cancer-associated fibroblasts (CAFs) have been shown to play a strong role in colorectal cancer metastasis, yet the underlying mechanism remains to be fully...

2022年1月4日 · Cancer-associated fibroblasts (CAFs) contribute to colorectal cancer (CRC) development, but the underlying mechanisms remain elusive. A new study published in Gastroenterology has demonstrated...

2025年3月18日 · 为了阐明myCAFs衍生外泌体（CAF-Exo）作用于CRC细胞的机制，作者提取外泌体并进行RNA测序，发现lncRNA PWAR6在myCAF-Exo中上调最为显著。同样，PWAR6在CAFs、myCAF-Exo和CRC肿瘤组织中的表达明显升高，而在CRC细胞系和健康肠上皮细胞系之间 …

2022年3月1日 · Cancer-associated fibroblasts (CAFs) play an important role in colorectal cancer (CRC) progression and predict poor prognosis in CRC patients. However, the cellular origins of CAFs remain unknown, making it challenging to therapeutically target these cells.

We first constructed a signature based on CAFs hallmark genes to predict the survival of CRC patients and further revealed that the tumor-suppressing microenvironment and dysregulated immune checkpoint genes in CRC tissues were partly …

2024年11月7日 · In the development of colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) play a pivotal role in establishing tumor-permissive extracellular matrix structures, angiogenesis, and modulating the immune status of the tumor microenvironment (TME), thereby influencing tumor metastasis and resistance to radiotherapy and chemotherapy.

2021年11月28日 · In this review, we will investigate the factors secreted by CAFs and their tumorigenic, metastatic and, prognostic roles. Figure 1 provides a summary of CAF-related pathways involved in CRC development and pathogenesis.

2025年1月5日 · Cancer-associated fibroblasts (CAFs) significantly influence tumor progression and therapeutic resistance in colorectal cancer (CRC). However, the distributions and functions of CAF subpopulations vary across the four consensus molecular subtypes (CMSs) of CRC.

2022年7月13日 · 癌症相关 成纤维细胞 (CAF) 已被证明在 结直肠癌转移 中发挥重要作用，但其潜在机制仍有待充分阐明。 使用 CRC 临床样本和离体 CAFs-CRC 共培养模型，发现 CAFs 在 CRC 中诱导富含 亮氨酸 的 Alpha-2-糖蛋白（LRG1）的表达，与原发灶相比，它在转移性 CRC肿瘤 组织中的表达更高。 研究进一步表明，CAFs 诱导的 LRG1 促进了伴随 EMT（上皮间质转化）诱导的 CRC 迁移和侵袭。 此外，该信号轴也在肝转移小鼠模型中得到证实，该模型显示 CAFs 诱 …