2018年2月28日 · Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) that stimulate oncogenic signaling in TEC. In this study, we evaluated the cross-talk between CAF and TEC isolated from tumors generated in a mouse model of KRAS/mut p53-induced pancreatic cancer (KPC mice).

2022年11月4日 · Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor microenvironment (TME) and influence cancer hallmarks, but without systematic...

2021年6月10日 · CAFs are highly heterogeneous stromal cells and their crosstalk with cancer cells is mediated by a complex and intricate signaling network consisting of transforming growth factor-beta,...

2023年7月3日 · Cancer-associated fibroblasts (CAFs), as a central component of the tumor microenvironment in primary and metastatic tumors, profoundly influence the behavior of...

2024年3月7日 · This review summarizes the current knowledge on CAF-TEC interactions, delineating the ambivalent roles of CAFs in tumor vasculature and exploring the potential of TECs in modulating CAF phenotypes. Additionally, it examines how these interactions influence the efficacy of existing anticancer treatments, while outlining the challenges and ...

2023年7月3日 · 肺 为了深入表征癌症中的tec，从人类和小鼠肺癌中富集pecam1+细胞进行scrna-seq，从而鉴定出17种已知和16种以前未识别的ec表型。对这种tec异质性的进一步研究揭示了非小细胞肺癌（nsclc）患者的血管生成特征与生存率之间的相关性。

2024年12月26日 · cafs通过代谢支持肿瘤细胞，如脂质丰富的abca8a+caf亚型为pdac肿瘤细胞提供脂质，psc衍生的cafs分泌脂质、丙氨酸等促进肿瘤细胞增殖；此外，cafs还可通过调节代谢物影响肿瘤细胞行为，如谷氨酰胺可用性受tem8+cafs调节，前列腺cafs将乳酸转运至肿瘤细胞增强其线 …

2017年12月19日 · Resident fibroblasts that contact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts (CAF) that stimulate oncogenic signaling in TEC. In this...

Both CAFs and TECs are emerging as pivotal regulators of the TME, engaging in multifaceted biological processes that significantly impact cancer progression, dissemination, and therapeutic responses. Yet, the intricate interplay between these stromal components and the orchestrated functions of each cell type remains incompletely elucidated.

本研究针对肿瘤相关细胞与肿瘤细胞间的相互作用问题，进行了体外诱导正常成纤维细胞和血管内皮细胞为肿瘤相关成纤维细胞 (CAF)和肿瘤相关血管内皮细胞 (TEC)，鉴定其相关性及对人卵巢癌细胞 (SKOV3)生物学行为影响的研究，为肿瘤微环境多靶标协同调控的肿瘤治疗新策略奠定实验基础。 实验结果表明，诱导培养后的人脐静脉血管内皮细胞 (HUVEC)和成纤维细胞系 (CNLMG)形态高度符合肿瘤细胞形态特征。 CCK8测试结果显示，肿瘤相关细胞和肿瘤细胞呈相互促进、相 …