2024年12月24日 · CAND1 (Cullin Associated And Neddylation Dissociated 1) is a Protein Coding gene. Diseases associated with CAND1 include Prostate Cancer and Peroxisome Biogenesis Disorder 6B. Among its related pathways are Innate Immune System and Metabolism of proteins.

2023年8月1日，哈尔滨医科大学潘振伟团队在《Nature Communications》发表题为“Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2”的研究论文，该研究发现CAND1在NAFLD患者，高脂喂养小鼠和PA诱导的肝细胞中蛋白和mRNA ...

Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene. [5] [6] [7]

编码的蛋白质与未被修饰的 cullin-RING 盒蛋白复合物结合，并作为 cullin neddylation 和 Skp1、cullin 和 F 盒泛素连接酶复合物组装和活性的抑制剂。 在哺乳动物细胞培养物中，这种蛋白质主要定位于细胞质。 前脂肪细胞中该基因的敲低导致脂肪生成受阻。 可变剪接导致多个转录本变体。 [RefSeq 提供，2016 年 7 月] This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub Proteasome …

2023年8月1日 · Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder with high morbidity and mortality. The current study aims to explore the role of Cullin-associated and...

Binding and ubiquitylation assays show that Cand1 is a protein exchange factor that accelerates the rate at which Cul1-Rbx1 equilibrates with multiple F box protein-Skp1 modules. Depletion of Cand1 from cells impedes recruitment of new F box proteins to pre-existing Cul1 and profoundly alters the cellular landscape of SCF complexes.

2024年1月4日 · Here we find that CAND1 inhibits CRL2-mediated protein degradation in human cells. This effect arises due to altered binding kinetics, involving CAND1 and CRL2 VHL, as we illustrate that...

2025年2月9日 · Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation. CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. miR-33a and CAND1 played an important role in lung cancer proliferation and cell migration

2013年3月27日 · Here, using highly quantitative mass spectrometry, we demonstrate that this problem is addressed by CAND1, a factor that controls the dynamics of the global cullin 1-RING ubiquitin ligase network...

2024年3月5日 · Title: Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation. CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum.