2024年12月24日 · CASP7 (Caspase 7) is a Protein Coding gene. Diseases associated with CASP7 include Kaposi Sarcoma and Cataract. Among its related pathways are TNFR1 Pathway and Apoptosis and survival FAS signaling cascades. Gene Ontology (GO) annotations related to this gene include cysteine-type endopeptidase activity and aspartic-type endopeptidase activity.

Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene. CASP7 orthologs [5] have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts.

胱天蛋白酶7 （英语：Caspase 7）是人类中由 CASP7 基因 编码的一种 酶。 该酶是一种参与 细胞凋亡 的 半胱氨酸蛋白酶。 几乎所有可获得完整基因组数据的 哺乳动物 中都已鉴定出CASP7 直向同源物。 [7] 鸟类 、 蜥蜴 、 滑体动物 和 真骨类 中也存在独特的直系同源物。 胱天蛋白酶7是 胱天蛋白酶 家族的成员，已被证明是 细胞凋亡 的执行蛋白。 胱天蛋白酶的连续激活在细胞凋亡的执行阶段发挥着核心作用。 胱天蛋白酶作为无活性 酶原 存在，由上游的胱天蛋白酶（胱天蛋 …

该基因编码半胱氨酸-天冬氨酸蛋白酶 (半胱天冬酶) 家族的成员。 半胱天冬酶的顺序激活在细胞凋亡的执行阶段起着核心作用。 半胱天冬酶作为无活性的酶原存在，其在保守的天冬氨酸残基处进行蛋白水解加工以产生大小两个亚基，它们二聚化形成活性酶。 编码蛋白的前体被 Caspase 3 和 10 切割，在细胞死亡刺激下被激活并诱导细胞凋亡。 已经观察到该基因编码多种亚型的可变剪接转录物变体。 [RefSeq 提供，2012 年 5 月] This gene encodes a member of the cysteine-aspartic …

研究人员发现，caspase-7引发了Rube Goldberg系列事件，使细胞以有序的方式死亡，该研究的资深作者Edward Miao博士说，他是杜克大学免疫学和 分子遗传学 和微生物学系的教授，之前是UNC微生物学和免疫学系的副教授。 有序的细胞死亡对于 免疫反应 至关重要。 然而，如果没有这种酶，垂死的细胞可能会剧烈爆炸并造成附带损害。 缪说，这项研究为探索治疗应用的令人兴奋的可能性奠定了基础，特别是如果caspase-7可以被增强或阻断。 “关于我们细胞的基本成分， …

2022年6月15日 · Mechanistically, caspase-7 counteracts gasdermin D pores and preserves cell integrity by cleaving and activating acid sphingomyelinase (ASM), which thereby generates copious amounts of ceramide to...

2025年1月4日 · The most robust finding is a rare CASP7 missense variant which improved when combined with results from stage 2 data sets. This study demonstrated that an enriched case design can strengthen genetic signals, thus allowing detection of associations that would otherwise be missed in a traditional case-control study.

2025年2月8日 · Results show that caspase-7 is phosphorylated by PAK2 at S239 which inhibits its activity by two divergent mechanisms prior to and following caspase activation: initial phosphorylation allosterically slows activation by upstream initiator caspases by impeding cleavage at the intersubunit linker and a second phosphorylation site directly blocks s...

Activated initiator caspases directly activate the executioner caspases-3 and/or -7, which lead to apoptosis or inflammation by cleaving specific sets of substrates. Together with caspase-3 and -6, caspase-7 belongs to the subgroup of executioner caspases (Lamkanfi et al., 2002).

2024年3月15日 · Caspase (CASP) is a family of proteases involved in cleavage and activation of gasdermin, the executor of pyroptosis. In humans, CASP3 and CASP7 recognize the same consensus motif DxxD, which is present in gasdermin E (GSDME). However, human GSDME is cleaved by CASP3 but not by CASP7. The underlying …