CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3.

2024年12月24日 · First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to …

新型番荔枝酰胺衍生物（ FLZ ）能增强BDNF/TrkB/CREB等信号通路，活化CREB，上调BCL-2，下调BAX并抑制caspase-3的活性，从而抑制淀粉样前体蛋白（APP）/早老素（PS1）转基因大鼠海马神经元凋亡。

The CREB binding protein (CBP) was first identified as a protein that specifically binds to the active phosphorylated form of the cyclic-AMP response element binding protein (CREB). CBP was initially defined as a transcriptional coactivator …

CREB binding protein (CBP) is a coactivator of transcription that can be independently regulated in neurons. CBP functions both as a platform for recruiting other required components of the transcriptional machinery and as a histone acetyltransferase (HAT) that alters chromatin structure.

首先将creb结合蛋白（cbp）鉴定为与环状amp反应元件结合蛋白（creb）的活性磷酸化形式特异性结合的蛋白。 CBP最初被定义为转录共激活因子，由于其较大的大小和多个蛋白结合域模块，其可以充当分子支架。

CBP [cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)-binding protein] is one of the most researched proteins for its therapeutic function. Several studies have identified its vast functions and interactions with other transcription factors to initiate cellular signals of survival.

Once serine 133 of CREB is phosphorylated, CREB interacts with its coactivator protein, CREB-binding protein (CBP), or p300 to initiate transcription of CREB-responsive genes (1-3). CBP is a cofactor for many other transcription factors and helps to stimulate transcription by modulating chromatin through histone acetylation and recruiting ...

2021年6月8日 · Recent efforts have identified specific and potent CBP/p300 inhibitors that target the acetyltransferase activity and the acetytllysine-binding bromodomain (BD) of CBP/p300. These compounds inhibit AR signaling and tumor growth in prostate cancer.

2025年2月9日 · First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition.