CBX-250 induces potent T cell mediated killing in vitro of leukemia cell lines with varying levels of target expression at sub-nanomolar EC 50 levels and exhibits highly effective tumor control in vivo against multiple AML cell line (CDX) murine models at doses as low as 0.005 mg/kg.

2024年11月5日 · CBX-250 induces potent T cell mediated killing in vitro of leukemia cell lines with varying levels of target expression at sub-nanomolar EC 50 levels and exhibits highly effective tumor control in vivo against multiple AML cell line (CDX) murine models at …

CBX-250 is the first candidate in Crossbow’s portfolio of novel investigative therapies that target intracellular cancer antigens using TCR-mimetics. The upcoming AACR presentation will focus on the potency, specificity, and safety of CBX-250 in targeting leukemic myeloid cells versus normal tissues, as demonstrated preclinically both in ...

2024年3月22日 · Here we report the preclinical characterization of CBX-250, a novel CG1/HLA-A2 TCRm-CD3 bispecific T-Cell Engager (TCE). CBX-250 induced potent T-cell activation and T-cell mediated killing of leukemia cell lines with varying levels of …

2024年3月5日 · CBX-250 is a first-in-class, potent, and specific T-cell engager for the treatment of myeloid leukemia. Abstract summarizing preclinical characteristics of CBX-250 selected for an oral...

For a 250cc single cylinder, performance is actually quite good, this four valve, DOHC, air & oil cooled motor as it produces 17.5kW of power at 8000rpm and 24Nm of torque at 6000rpm, surprising considering that the compression ratio is fairly low at 9.3 : 1.

2024年11月14日 · 这颗249cc的引擎拥有28匹马力，它不是追求高转速的极致性能，但中低速域的动力输出却相当有力，能够提供很不错的加速表现。 115公斤，加上强劲的扭力引擎，使其马力重量比达到了4.1公斤/匹马力，这样的数据在同级别车款中堪称佼佼者。 轻量化与灵活的设计在摩托车领域永远有着自己的立足之地。 即便市场环境未必总是有利，但真正热爱骑行的人们，总会为这样的精品而怦然心动。 这款车虽然已经成为历史，但它所代表的那份激情与自由，依旧在每 …

2025年1月16日 · Manufacturer – Make – Model – Year: Honda CBX 250 1987 Motorcycle Style: Standard . ENGINE SPECS Engine Type: 249 cc, 4-Stroke, Air Cooled, Single Engine Bore and Stroke: 75 mm x 56.5 mm Valves 2 valves/cylinder Claimed Horsepower: 24 hp (17.9 kW) @ 8000 rpm Maximum Torque: 20 Nm (14.8 ft. lbs) @ 9000 rpm . Transmission type: 6 speed

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