Chromobox protein homolog 3 is a protein that is encoded by the CBX3 gene in humans. [5] [6] At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin.

2024年12月24日 · CBX3 (Chromobox 3) is a Protein Coding gene. Diseases associated with CBX3 include Hyperoxaluria, Primary, Type I and Hutchinson-Gilford Progeria Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and …

2022年11月22日 · CBX3表达显示出区分肿瘤组织和正常组织的良好能力，在8个肿瘤中AUC值>0.9（图2A-H），包括BLCA，BRCA，HNSC，COAD，LIHC，LUAD，LUSC和STAD。 在其他肿瘤中，除UCEC外，AUC值>0.7。 图2. 此外，为了评估CBX3在蛋白质水平上的表达，评估了HPA数据集的免疫组化结果，并将这些结果与TCGA的CBX3基因表达数据进行了比较。 如图3A-F所示，两个数据库的数据分析结果是一致的。 正常的乳房、结肠、肺和胃组织显示中 …

2024年5月23日 · Here, we demonstrate that chromobox protein homolog 3 (CBX3) binds replication protein A 32-kDa subunit (RPA2) and regulates RPA2 retention at stalled replication forks. CBX3 is recruited to stalled replication forks by RPA2 and inhibits ring finger and WD repeat domain 3 (RFWD3)–facilitated replication restart.

2023年8月26日 · Here we describe that a wide spectrum of human cancers harbors a co-amplification of CBX3 gene with either EGFR or RAC1, which yields a statistically significant increase of both mRNA and protein...

探讨CBX3 在肺腺癌中的表达与肺腺癌患者预后的关系,并研究CBX3对A549 肺腺癌细胞增殖、迁移和侵袭能力的影响。

2022年4月22日 · Our study reported the identification of CBX3 as a potential therapeutic target for GBM. Briefly, we found that, CBX3 is significantly upregulated in GBM and reduces patient survival. In...

Genome-wide localization analysis reveals CBX3 binding at genic regions, which strongly correlates with gene activity across multiple cell types. Depletion of CBX3 resulted in down-regulation of a subset of target genes. Loss of CBX3 binding leads to a more dramatic accumulation of unspliced nascent transcripts.

2011年4月14日 · Genome-wide localization analysis reveals CBX3 binding at genic regions, which strongly correlates with gene activity across multiple cell types. Depletion of CBX3 resulted in down-regulation of a subset of target genes. Loss of CBX3 binding leads to a more dramatic accumulation of unspliced nascent transcripts.

2021年2月1日 · The early function of CBX3 in generating pluripotency is functionally linked to the heterochromatin anchoring protein SENP7, and release of CBX3 from chromatin is ultimately necessary for acquisition of pluripotency [74].