2023年5月29日 · Hemoglobin C is a common hemoglobin variant that has a single amino acid substitution (lysine substituted for the glutamate) in the sixth position of the beta-globin chain. The patients with hemoglobin C trait (HbAC) are phenotypically normal, while patients with hemoglobin C disease (HbCC) may have chronic hemolytic anemia.

2018年9月21日 · Hemoglobin C disease (Hb CC) is a mild disorder that generally does not cause any symptoms and is associated with a normal life expectancy. Affected individuals...

Hemoglobin C, S-C, and E diseases are inherited conditions characterized by gene mutations that affect the hemoglobin (the protein that carries oxygen) in red blood cells. These red blood cells are destroyed more quickly than others, resulting in chronic anemia.

2024年10月27日 · Hemoglobin C disorders are one of the most common structural hemoglobin variants. Hemoglobin C occurs due to a substitution of lysine for glutamic acid (glutamate) in position 6 of the beta-globin gene (leading to an abnormal hemoglobin A).

2023年5月29日 · Hemoglobin C (Hb C), on the other hand, is one of the common structural variants of normal hemoglobin in which lysine is substituted for the glutamate in the sixth position of the beta-globin chain making it less soluble than Hb A. Hemoglobin C can either be in the homozygous states (Hb CC) or in the heterozygous states (Hb SC, Hb AC).

血红蛋白 C、S-C 和 E 病是遗传性疾病，特征为影响红细胞内血红蛋白（携带氧气的蛋白质）的基因突变。 这些红细胞比其他红细胞更快被破坏，导致慢性贫血。 （也可参见贫血概述和镰状细胞病。 血红蛋白 C 病大多见于有非洲或美国黑人血统的人群。 在美国，有非洲或美国黑人血统的人群中有 2%～3% 携带血红蛋白 C 病致病基因的一个拷贝。 然而，必须同时有 2 个异常基因才能发病。 一般来说，症状少见。 贫血严重性不等。 本病患者可出现脾脏肿大和轻度黄疸，但不会 …

2024年3月31日 · Hemoglobin C is an abnormal type of hemoglobin, the protein in red blood cells that carries oxygen. It is a type of hemoglobinopathy. The disease is caused by a problem with a gene called beta globin. The disease most often occurs in African Americans. You are more likely to have hemoglobin C disease if someone in your family has had it.

Hemoglobin C disease is a hemoglobinopathy that causes symptoms of a hemolytic anemia. (See also Overview of Hemolytic Anemia.) The prevalence of detectable hemoglobin (Hb) C in people in the United States with African ancestry is approximately 2 to 3%. Patients who are heterozygous are asymptomatic.

Homozygous hemoglobin C disease (Hb CC) manifests as a milder disease compared with SCD. Mild splenomegaly and hemolysis may be present. In addition, vasoocclusive crises do not occur. Heterozygous hemoglobin C trait (Hb AC) is asymptomatic. A mild to moderate, normochromic, normocytic anemia occurs in homozygous Hb C disease.

2023年5月29日 · Hemoglobin C is a benign hemoglobinopathy that can cause mild hemolytic anemia. Overall people with hemoglobin C have normal growth and development and a normal life expectancy. Complications. Hemoglobin C disease, due to continued hemolysis may produce cholelithiasis due to pigmented gallstones.