CC3 inhibits the nuclear import of proteins possessing either the classical nuclear localization signal or the M9 signal recognized by transportin. CC3 also inhibits nuclear translocation of transportin itself.

2005年5月6日 · Binding of CC3 to importins inhibits the nuclear transport of proteins with either the classical nuclear localization signal or the M9 signal recognized by importin β2. Cells modified to overexpress CC3 have slower rates of nuclear transport and higher sensitivity to death signals.

2010年4月7日 · CC3 inhibits nuclear import of proteins with either the classic nuclear localization signal (NLS) recognized by importin α:β 1, or the M9 signal recognized by transportin (importin β2). Cells modified to express higher levels of CC3 are predisposed to apoptosis and have a slower rate of nuclear import [ 18 ].

Binding of CC3 to importins inhibits the nuclear transport of proteins with either the clas-sical nuclear localization signal or the M9 signal recognized by importin 2. Cells modified to overexpress CC3 have slower rates of nuclear transport and higher sensitivity to death sig-nals.

2010年12月12日 · CC3 inhibits nuclear import of proteins with either the classic nuclear localization signal (NLS) recognized by importin α:β1, or the M9 signal recognized by transportin (importin β2).

To clarify details of the CC3 structural family and ligand binding properties, we have determined the crystal structure of CC3 at 1.7-A resolution. CC3 has a short chain dehydrogenase reductase fold and binding specificity for NADPH, yet it is unlikely to be normally enzymatically active because it is monomeric.

CC3 binds directly to the karyopherins of the importin beta family in a RanGTP-insensitive manner and associates with nucleoporins in vivo. CC3 inhibits the nuclear import of proteins possessing either the classical nuclear localization signal or the M9 signal recognized by transportin.

2004年9月1日 · CC3 inhibits the nuclear import of proteins possessing either the classical nuclear localization signal or the M9 signal recognized by transportin. CC3 also inhibits nuclear translocation of ...

Binding of CC3 to importins inhibits the nuclear transport of proteins with either the classical nuclear localization signal or the M9 signal recognized by importin β2. Cells modified to overexpress CC3 have slower rates of nuclear transport and higher sensitivity to death signals.

CC3 binds directly to the karyopherins of the importin β family in a RanGTP-insensitive manner and associates with nucleoporins in vivo.