2021年10月1日 · Our study aimed to evaluate the effects of sub-chronic systemic treatment with CBD (0.3, 3, 10, or 30 mg/kg, i.p.) in male in rats submitted to chronic constriction injury of the …

2022年10月28日 · We hypothesized that CBD in combination with sub-therapeutic doses of morphine could enhance morphine antinociception, and that CBD could attenuate morphine …

2023年7月1日 · FKBP5 Y113 mutation (Y113A) alleviated the effect of CBD inhibiting LPS-induced pro-inflammatory factors overproduction. Furthermore, systemic administration of …

CBD effectiveness was also demonstrated in a chronic constriction injury (CCI) animal model of neuropathic pain. Both oral and subcutaneous administration of CBD resulted in reduced …

Our results demonstrated that CBD promoted the reversal of CPP at 3 and 10mg/kg. In CCI animals, CBD was able to attenuate the increase in neuronal hyperactivity, measured by FosB …

Cannabidiol (CBD) has been considered a promising treatment for these conditions. This study investigated whether chronic systemic treatment with CBD alters pain in high- (CHF) and low …

与载体 / cci、flx/cci 和 cbd（3 mg/kg）治疗组相比，30 mg/kg 的 cbd 治疗减轻了 cci 大鼠的机械性异常性疼痛。在所有 cci 大鼠中，np 都与抑郁相关行为有关。flx 仅显著减弱了类似抑郁的 …

2024年6月8日 · To study the antinociceptive potential of cannabidiol (CBD) and its fluorinated analog PECS-101 (former HUF-101), we induced unilateral chronic constriction injury of the …

FKBP5 Y113 mutation (Y113A) alleviated the effect of CBD inhibiting LPS-induced pro-inflammatory factors overproduction. Furthermore, systemic administration of CBD inhibited …

2023年8月24日 · In CCI animals, CBD was able to attenuate the increase in neuronal hyperactivity, measured by FosB protein expression, in the regions of the corticolimbic circuit: …